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Thalidomide-5-methyl

Name: Thalidomide-5-methyl
Brand: TargetMol
SKU: T40503
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40503Cas No. 40313-92-6

Thalidomide-5-methyl is a Thalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein.

Thalidomide-5-methyl

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Purity: 99.48%

Catalog No. T40503Cas No. 40313-92-6

Thalidomide-5-methyl is a Thalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein.

Pack Size	Price	Availability
1 mg	$63	In Stock
5 mg	$155	In Stock
10 mg	$233	In Stock
25 mg	$398	In Stock
50 mg	$559	In Stock
100 mg	$756	In Stock
200 mg	$1,020	In Stock
1 mL x 10 mM (in DMSO)	$139	In Stock

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Batch Information

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Purity:99.48%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Thalidomide-5-methyl is a Thalidomide-based cereblon (CRBN) ligand used for the recruitment of CRBN protein.
In vitro	PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by containing two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the desired protein [1].

Chemical Properties

Molecular Weight	272.26
Formula	C₁₄H₁₂N₂O₄
Cas No.	40313-92-6
Smiles	O=C1N(C(=O)C=2C1=CC(C)=CC2)C3C(=O)NC(=O)CC3
Relative Density.	1.448 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (183.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6730 mL	18.3648 mL	36.7296 mL	183.6480 mL
5 mM	0.7346 mL	3.6730 mL	7.3459 mL	36.7296 mL
10 mM	0.3673 mL	1.8365 mL	3.6730 mL	18.3648 mL
20 mM	0.1836 mL	0.9182 mL	1.8365 mL	9.1824 mL
50 mM	0.0735 mL	0.3673 mL	0.7346 mL	3.6730 mL
100 mM	0.0367 mL	0.1836 mL	0.3673 mL	1.8365 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc