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Inclacumab

Catalog No. T78288 CAS 1256258-86-2

Synonyms: Anti-Human selectin P Recombinant Antibody

Inclacumab, a humanized monoclonal IgG4 antibody (Anti-Human Selectin P Recombinant Antibody), specifically binds to P-selectin with a dissociation constant (Kd) of 9.9 nM. It effectively prevents the interaction between P-selectin and P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide, with a half-maximal inhibitory concentration (IC50) of 1.9 µg/mL, and robustly impedes cell adhesion [1] [2] [3].

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Inclacumab

Inclacumab, CAS 1256258-86-2

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Description	Inclacumab, a humanized monoclonal IgG4 antibody (Anti-Human Selectin P Recombinant Antibody), specifically binds to P-selectin with a dissociation constant (Kd) of 9.9 nM. It effectively prevents the interaction between P-selectin and P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide, with a half-maximal inhibitory concentration (IC50) of 1.9 µg/mL, and robustly impedes cell adhesion [1] [2] [3].
In vitro	Inclacumab, at concentrations of 0.4-40 μg/mL and applied for 5 minutes, markedly reduces P-Selectin-mediated adhesion of both whole blood and isolated white blood cells, with a pronounced effect on the latter [1]. Demonstrating high affinity for P-Selectin with a dissociation constant (Kd) of 9.9 nM [2], Inclacumab also effectively hinders the binding of PSGL-1 mimetic peptide to P-Selectin, with an inhibitory concentration (IC50) of 1.9 µg/mL, and obstructs the adhesion of PSGL-1 positive cells to P-Selectin, with an IC50 of 430 ng/mL [2]. Additionally, Inclacumab, in a range of 0-100 μg/mL, dose-dependently diminishes levels of TRAP-induced platelet-leukocyte aggregates, achieving an IC50 of 1.4 μg/mL [3].
In vivo	Inclacumab, at a single subcutaneous dose of 4 mg/kg, attenuates TRAP- and ADP-induced platelet activation (PLA) in cynomolgus monkeys [3]. Additionally, weekly intravenous doses ranging from 2 to 50 mg/kg over a period of 13 weeks effectively inhibit TRAP-induced PLA in the same species [3].

Synonyms	Anti-Human selectin P Recombinant Antibody
Molecular Weight	N/A
CAS No.	1256258-86-2

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Inclacumab 1256258-86-2 Anti-Human selectin P Recombinant Antibody inhibitor inhibit

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