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Procyanidin B3

Name: Procyanidin B3
Brand: TargetMol
SKU: TN1150
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1150Cas No. 23567-23-9

Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.

Procyanidin B3

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Purity: 99.71%

Catalog No. TN1150Cas No. 23567-23-9

Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$222	In Stock	In Stock
25 mg	$375	In Stock	In Stock
50 mg	$552	-	In Stock
1 mL x 10 mM (in DMSO)	$177	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.71%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.

In vitro

We observed that Procyanidin B3 inhibited H(2)O(2)-induced apoptosis in primary chondrocytes, suppressed H(2)O(2)- or IL-1?-induced nitric oxide synthase (iNOS) production, and prevented IL-1?-induced suppression of chondrocyte differentiation marker gene expression in primary chondrocytes. Moreover, Procyanidin B3 treatment enhanced the early differentiation of ATDC5 cells. To examine whether Procyanidin B3 prevents cartilage destruction in vivo, OA was surgically induced in C57BL/6J mice followed by oral administration of Procyanidin B3 or vehicle control. Daily oral Procyanidin B3 administration protected articular cartilage from OA and prevented chondrocyte apoptosis in surgically-induced OA joints. Furthermore, Procyanidin B3 administration prevented heterotopic cartilage formation near the surgical region. iNOS protein expression was enhanced in the synovial tissues and the pseudocapsule around the surgical region in OA mice fed a control diet, but was reduced in mice that received Procyanidin B3. Together, these data indicated that in the OA model, Procyanidin B3 prevented OA progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS.

Chemical Properties

Molecular Weight	578.52
Formula	C₃₀H₂₆O₁₂
Cas No.	23567-23-9
Smiles	O[C@H]1Cc2c(O)cc(O)c([C@H]3[C@H](O)[C@H](Oc4cc(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1
Relative Density.	1.705g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (259.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7285 mL	8.6427 mL	17.2855 mL	86.4274 mL
5 mM	0.3457 mL	1.7285 mL	3.4571 mL	17.2855 mL
10 mM	0.1729 mL	0.8643 mL	1.7285 mL	8.6427 mL
20 mM	0.0864 mL	0.4321 mL	0.8643 mL	4.3214 mL
50 mM	0.0346 mL	0.1729 mL	0.3457 mL	1.7285 mL
100 mM	0.0173 mL	0.0864 mL	0.1729 mL	0.8643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc