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Phenytoin sodium

Name: Phenytoin sodium
Brand: TargetMol
SKU: T0008
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0008Cas No. 630-93-3

Alias Diphenylhydantoin Sodium, Diphantoine, Dilantin sodium, 5,5-Diphenylhydantoin sodium salt

Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .

Phenytoin sodium

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Purity: 99.92%

Catalog No. T0008Alias Diphenylhydantoin Sodium, Diphantoine, Dilantin sodium, 5,5-Diphenylhydantoin sodium saltCas No. 630-93-3

Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$45	In Stock	In Stock
1 g	$53	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Phenytoin sodium AI Summary

Phenytoin sodium exhibits a diverse range of bioactivities, prominently including cognitive enhancement, anticonvulsant properties, and antiviral effects. It demonstrates cognitive activity by improving passive avoidance learning in mice at lower doses (1.25 mg/kg to 5 mg/kg) with retention rates ranging from 75.0% to 90.0%, but higher doses (10 mg/kg to 80 mg/kg) result in decreased retention rates from 15.0% to 55.0%. As an anticonvulsant, it shows efficacy across various models: in mice and rats, it inhibits maximal electroshock-induced seizures with significant protection rates at doses between 7.5 mg/kg and 50 mg/kg, and displays activity in pentylenetetrazole-induced seizure models. At the antiviral level, it inhibits SARS-CoV-2 induced cytotoxicity and the SARS-CoV-2 3CL-Pro protease. Additionally, it is effective against influenza NS1 protein function and Lassa virus. The compound also interferes with various other biological targets such as the MLL CXXC domain - DNA interaction, cytochrome P450 2C9, and acetylcholine muscarinic M1 receptor, and shows broad antimicrobial activity against fungal species like Candida albicans and Cryptococcus neoformans, and bacterial strains including E. coli and Staphylococcus aureus MRSA. However, it exhibits neurotoxicity with low TD50 values in rotarod tests, indicating a moderate margin of safety between its therapeutic and toxic doses. The compound has an estimated ALD50 of 1000 mg/kg in rats, suggesting a relatively high acute toxicity threshold..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .
Synonyms	Diphenylhydantoin Sodium, Diphantoine, Dilantin sodium, 5,5-Diphenylhydantoin sodium salt

Chemical Properties

Molecular Weight	274.25
Formula	C₁₅H₁₁N₂NaO₂
Cas No.	630-93-3
Smiles	[Na+].O=C1NC(C(=O)[N-]1)(c1ccccc1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 9 mg/mL (32.82 mM), Sonication is recommended.

DMSO: 13.16 mg/mL (47.99 mM), Sonication is recommended.

H2O: 3 mg/mL (10.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6463 mL	18.2315 mL	36.4631 mL	182.3154 mL
5 mM	0.7293 mL	3.6463 mL	7.2926 mL	36.4631 mL
10 mM	0.3646 mL	1.8232 mL	3.6463 mL	18.2315 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1823 mL	0.9116 mL	1.8232 mL	9.1158 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc