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Serpin A12 Protein, Human, Recombinant (GST)

Catalog No. TMPJ-00262
Synonyms: Visceral Adipose Tissue-Derived Serine Protease Inhibitor, Vaspin, OL-64, SERPINA12, Serpin A12, Visceral Adipose-Specific Serpin

Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets, nine α-helices, and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Serpin A12 Protein, Human, Recombinant (GST)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 129.00
50 μg 5 days $ 390.00
500 μg 5 days $ 1,530.00
1 mg 5 days $ 2,180.00
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Biological Description
Technical Params
Product Properties
Description Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets, nine α-helices, and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.
Species Human
Expression System E. coli
Tag N-GST
Accession Number Q8IW75
Synonyms Visceral Adipose Tissue-Derived Serine Protease Inhibitor, Vaspin, OL-64, SERPINA12, Serpin A12, Visceral Adipose-Specific Serpin
Amino Acid Leu21-Lys414
Construction Recombinant Human Serine Protease Inhibitor-clade A12 is produced by our E.coli expression system and the target gene encoding Leu21-Lys414 is expressed with a GST tag at the N-terminus.
Protein Purity Greater than 80% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 72 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 160mM NaCl, 0.2mM PMSF, 1mM DTT, 10% Glycerine, pH 7.2.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Research Background Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets, nine α-helices, and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.

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Keywords

Serpin A12 Protein, Human, Recombinant (GST) OL64 Visceral Adipose Tissue-Derived Serine Protease Inhibitor Vaspin SERPINA-12 OL 64 OL-64 SERPINA 12 SERPINA12 Serpin A12 Visceral Adipose-Specific Serpin recombinant recombinant-proteins proteins protein

 

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