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Anti-CRBN Polyclonal Antibody
Catalog No. TMAB-04638 Copy Product Info
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Anti-CRBN Polyclonal Antibody is a Rabbit antibody targeting CRBN. Anti-CRBN Polyclonal Antibody can be used in WB.
Anti-CRBN Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-04638
Anti-CRBN Polyclonal Antibody is a Rabbit antibody targeting CRBN. Anti-CRBN Polyclonal Antibody can be used in WB.
Anti-CRBN Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CRBN Polyclonal Antibody is a Rabbit antibody targeting CRBN. Anti-CRBN Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Pig,Cow,Rabbit,Sheep) |
| Verified Activity | Sample: Lane 1: Human A431 cell lysates Lane 2: Human 293T cell lysates Primary: Anti-CRBN (TMAB-04638) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kDa Observed band size: 55 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Membrane; Peripheral membrane protein |
| Tissue Specificity | Widely expressed. Highly expressed in brain. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation. |
| Immunogen | KLH conjugated synthetic peptide: human CRBN |
| Antigen Species | Human |
| Gene Name | CRBN |
| Gene ID | |
| Protein Name | Protein cereblon |
| Uniprot ID | |
| Function | Protein cereblon modulates cell surface expression of KCNT1 and may be involved in memory and learning. It is highly expressed in brain and defects in CRBN are the cause of non syndromic mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. Although it contains a Lon domain also found in proteases of the peptidase S16 family, it does not contain the ATP binding and catalytic domains, suggesting that it has no protease activity. |
| Molecular Weight | Theoretical: 51 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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