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R 59-022 hydrochloride

Name: R 59-022 hydrochloride
Brand: TargetMol
SKU: T72322
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T72322Cas No. 93076-98-3

Alias DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride, DKGI-I hydrochloride, Diacylglycerol kinase inhibitor I hydrochloride

R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R 59-022 enhances thrombin-induced triglyceride production in platelets and inhibits the production of phosphatidic acid in neutrophils. R 59-022 enhances thrombin-induced diglyceride production in platelets and inhibits phosphatidic acid production in neutrophils.

R 59-022 hydrochloride

🥰Excellent

Purity: 98.33%

Catalog No. T72322Alias DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride, DKGI-I hydrochloride, Diacylglycerol kinase inhibitor I hydrochlorideCas No. 93076-98-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$478	In Stock	In Stock
100 mg	$688	-	In Stock
500 mg	$1,420	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.33%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R 59-022 enhances thrombin-induced triglyceride production in platelets and inhibits the production of phosphatidic acid in neutrophils. R 59-022 enhances thrombin-induced diglyceride production in platelets and inhibits phosphatidic acid production in neutrophils.
Targets&IC50	DGK:2.8 µM
In vitro	R 59-022 (10 μM; 1 min) Hydrochloride enhances platelet aggregation.[1] R 59-022 (30 μM; 0-60 min) Hydrochloride increases the release of norepinephrine in chromaffin cells.[2] R 59-022 (40 μM; 30 min) Hydrochloride activates PKC in HeLa and U87 cells.[3] R 59-022 (0-10 μM; 4 h) Hydrochloride blocks the entry of EBOV GP into Vero cells.[4]
In vivo	R 59-022 (2 mg/kg; i.p.; 12 days) significantly increased the median survival of SCID mice implanted with U87 GBM cells.[6]
Synonyms	DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride, DKGI-I hydrochloride, Diacylglycerol kinase inhibitor I hydrochloride

Chemical Properties

Molecular Weight	496.04
Formula	C₂₇H₂₇ClFN₃OS
Cas No.	93076-98-3
Smiles	Cl.O=C1C(=C(N=C2SC=CN21)C)CCN3CCC(=C(C=4C=CC=CC4)C5=CC=C(F)C=C5)CC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (110.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0160 mL	10.0798 mL	20.1597 mL	100.7983 mL
5 mM	0.4032 mL	2.0160 mL	4.0319 mL	20.1597 mL
10 mM	0.2016 mL	1.0080 mL	2.0160 mL	10.0798 mL
20 mM	0.1008 mL	0.5040 mL	1.0080 mL	5.0399 mL
50 mM	0.0403 mL	0.2016 mL	0.4032 mL	2.0160 mL
100 mM	0.0202 mL	0.1008 mL	0.2016 mL	1.0080 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc