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CDK5 inhibitor 20-223

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Catalog No. T36742Cas No. 865317-30-2
Alias CP668863, CP 668863

CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.

CDK5 inhibitor 20-223

CDK5 inhibitor 20-223

😃Good
Catalog No. T36742Alias CP668863, CP 668863Cas No. 865317-30-2
CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$95-In Stock
50 mg$7896-8 weeks6-8 weeks
100 mg$1,1806-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.
Targets&IC50
CDK2/CDK5:362 nM
In vitro
CDK5 inhibitor 20-223 inhibits CDK2/CDK5 (IC₅₀ ≈ 362 nM), causes cell cycle arrest, reduces RB and FAK phosphorylation, and blocks CRC cell migration. CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells[1].
In vivo
In mice, CDK5 inhibitor 20-223 (8 mg/kg, 3 weeks) significantly reduced tumor growth without toxicity and lowered pFAK levels in tumors[1].
SynonymsCP668863, CP 668863
Chemical Properties
Molecular Weight305.37
FormulaC19H19N3O
Cas No.865317-30-2
SmilesO=C(NC1=NNC(=C1)C2CCC2)CC=3C=CC=4C=CC=CC4C3
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (261.98 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 5 mg/mL (16.37 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2747 mL16.3736 mL32.7472 mL163.7358 mL
5 mM0.6549 mL3.2747 mL6.5494 mL32.7472 mL
10 mM0.3275 mL1.6374 mL3.2747 mL16.3736 mL
20 mM0.1637 mL0.8187 mL1.6374 mL8.1868 mL
50 mM0.0655 mL0.3275 mL0.6549 mL3.2747 mL
100 mM0.0327 mL0.1637 mL0.3275 mL1.6374 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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