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CDK5 inhibitor 20-223

Catalog No. T36742 CAS 865317-30-2

Synonyms: CDK5 inhibitor 20-223

CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].

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CDK5 inhibitor 20-223 Chemical Structure

CDK5 inhibitor 20-223, CAS 865317-30-2

Pack Size	Availability	Price/USD
2 mg	5 days	$ 95.00
50 mg	6-8 weeks	$ 789.00
100 mg	6-8 weeks	$ 1,180.00

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Biological Description

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Description	CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].
Targets&IC50	CDK2:6.0 nM (IC50), CDK5:8.8 nM (IC50)
In vitro	CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines[1].CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines[1]. Cell Viability Assay[1] Cell Line: CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells
In vivo	CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice[1]. Animal Model: Athymic nude mice[1]

Synonyms	CDK5 inhibitor 20-223
Molecular Weight	305.37
Formula	C19H19N3O
CAS No.	865317-30-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Caroline M Robb, et al. Characterization of CDK(5) Inhibitor, 20-223 (Aka CP668863) for Colorectal Cancer Therapy. Oncotarget. 2017 Dec 28;9(4):5216-5232.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CDK5 inhibitor 20-223 865317-30-2 CDK5 inhibitor 20223 CDK5 inhibitor 20 223 CDK-5 inhibitor 20-223 inhibitor inhibit

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