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CDK5 inhibitor 20-223

Name: CDK5 inhibitor 20-223
Brand: TargetMol
SKU: T36742
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36742Cas No. 865317-30-2

Alias CP668863, CP 668863

CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.

CDK5 inhibitor 20-223

😃Good

Catalog No. T36742Alias CP668863, CP 668863Cas No. 865317-30-2

Pack Size	Price	Availability
2 mg	$95	In Stock
50 mg	$789	6-8 weeks
100 mg	$1,180	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.
Targets&IC50	CDK2/CDK5:362 nM
In vitro	CDK5 inhibitor 20-223 inhibits CDK2/CDK5 (IC₅₀ ≈ 362 nM), causes cell cycle arrest, reduces RB and FAK phosphorylation, and blocks CRC cell migration. CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells[1].
In vivo	In mice, CDK5 inhibitor 20-223 (8 mg/kg, 3 weeks) significantly reduced tumor growth without toxicity and lowered pFAK levels in tumors[1].
Alias	CP668863, CP 668863

Chemical Properties

Molecular Weight	305.37
Formula	C₁₉H₁₉N₃O
Cas No.	865317-30-2
Smiles	O=C(NC1=NNC(=C1)C2CCC2)CC=3C=CC=4C=CC=CC4C3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (261.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2747 mL	16.3736 mL	32.7472 mL	163.7358 mL
5 mM	0.6549 mL	3.2747 mL	6.5494 mL	32.7472 mL
10 mM	0.3275 mL	1.6374 mL	3.2747 mL	16.3736 mL
20 mM	0.1637 mL	0.8187 mL	1.6374 mL	8.1868 mL
50 mM	0.0655 mL	0.3275 mL	0.6549 mL	3.2747 mL
100 mM	0.0327 mL	0.1637 mL	0.3275 mL	1.6374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc