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CDK5 inhibitor 20-223

Name: CDK5 inhibitor 20-223
Brand: TargetMol
SKU: T36742
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36742Cas No. 865317-30-2

Alias CP668863, CP 668863

CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.

CDK5 inhibitor 20-223

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Catalog No. T36742Alias CP668863, CP 668863Cas No. 865317-30-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$67	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.
Targets&IC50	CDK2/CDK5:362 nM
In vitro	CDK5 inhibitor 20-223 inhibits CDK2/CDK5 (IC₅₀ ≈ 362 nM), causes cell cycle arrest, reduces RB and FAK phosphorylation, and blocks CRC cell migration. CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells[1].
In vivo	In mice, CDK5 inhibitor 20-223 (8 mg/kg, 3 weeks) significantly reduced tumor growth without toxicity and lowered pFAK levels in tumors[1].
Synonyms	CP668863, CP 668863

Chemical Properties

Molecular Weight	305.37
Formula	C₁₉H₁₉N₃O
Cas No.	865317-30-2
Smiles	O=C(NC1=NNC(=C1)C2CCC2)CC=3C=CC=4C=CC=CC4C3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (261.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (16.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2747 mL	16.3736 mL	32.7472 mL	163.7358 mL
5 mM	0.6549 mL	3.2747 mL	6.5494 mL	32.7472 mL
10 mM	0.3275 mL	1.6374 mL	3.2747 mL	16.3736 mL
20 mM	0.1637 mL	0.8187 mL	1.6374 mL	8.1868 mL
50 mM	0.0655 mL	0.3275 mL	0.6549 mL	3.2747 mL
100 mM	0.0327 mL	0.1637 mL	0.3275 mL	1.6374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc