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SU3327

Name: SU3327
Brand: TargetMol
SKU: T13018
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13018Cas No. 40045-50-9

Alias halicin

SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).

SU3327

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Purity: 98.39%

Catalog No. T13018Alias halicinCas No. 40045-50-9

SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).

Pack Size	Price	Availability
2 mg	$32	In Stock
5 mg	$59	In Stock
10 mg	$97	In Stock
25 mg	$183	In Stock
50 mg	$328	In Stock
100 mg	$497	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Purity:98.39%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
Targets&IC50	JNK:0.7 μM , JNK-JIP:239 nM
In vitro	TNF-α stimulated phosphorylation of c-Jun in HeLa cells inhibited by SU3327 with EC50 of 6.23 μM[1]. SU3327 (25 nM) pretreatment of human-derived cerebral microvascular endothelial cells (hCMEC/D3) effectively reduces LPS-induced polymorphonuclear leukocytes (PMN) rolling/adhesion to hCMEC/D3, prevents activation of AP-1, and significantly reduces expression of VCAM-1[3].
In vivo	In male BKS.Cg-+Leprdb/+Leprdb/OlaHsd db/db mice, SU3327 (25 mg/kg; intraperitoneal injection; ) treatment possesses the ability to restore insulin sensitivity in mice models of diabetes[1]. SU3327 has favorable microsomal and plasma stability (T1/2 = 27 min)[1].
Synonyms	halicin

Chemical Properties

Molecular Weight	261.3
Formula	C₅H₃N₅O₂S₃
Cas No.	40045-50-9
Smiles	Nc1nnc(Sc2ncc(s2)[N+]([O-])=O)s1
Relative Density.	1.888g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (239.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8270 mL	19.1351 mL	38.2702 mL	191.3509 mL
5 mM	0.7654 mL	3.8270 mL	7.6540 mL	38.2702 mL
10 mM	0.3827 mL	1.9135 mL	3.8270 mL	19.1351 mL
20 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5675 mL
50 mM	0.0765 mL	0.3827 mL	0.7654 mL	3.8270 mL
100 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc