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Anti-p53 Antibody (5M213)

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Catalog No. TMAC-02992

Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in FCM,ICC,IF,IHC,IP,WB.

Anti-p53 Antibody (5M213)

Anti-p53 Antibody (5M213)

😃Good
Catalog No. TMAC-02992
Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in FCM,ICC,IF,IHC,IP,WB.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in FCM,ICC,IF,IHC,IP,WB.
Ig Type
IgG
Clone
5M213
Reactivity
Human
Verified Activity
1. Western blot analysis of p53 on 293 cell using p53 antibody at 1/500 dilution.
2. Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using p53 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using p53 antibody. Counter stained with hematoxylin.
4. Flow cytometric analysis of Daudi cells with p53 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
Application
Recommended Dose
WB: 1:500; IHC: 1:100; ICC: 1:100-500; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundActs as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 53 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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