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Anti-p53 Antibody (5M213)
😃Good
Catalog No. TMAC-02992
Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in FCM,ICC,IF,IHC,IP,WB.
Anti-p53 Antibody (5M213)
Anti-p53 Antibody (5M213)
😃Good
Catalog No. TMAC-02992
Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in FCM,ICC,IF,IHC,IP,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in FCM,ICC,IF,IHC,IP,WB. |
| Ig Type | IgG |
| Clone | 5M213 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of p53 on 293 cell using p53 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using p53 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using p53 antibody. Counter stained with hematoxylin. 4. Flow cytometric analysis of Daudi cells with p53 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.     |
| Application | |
| Recommended Dose | WB: 1:500; IHC: 1:100; ICC: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 53 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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