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Anti-p53 Antibody (5M213)

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Catalog No. TMAC-02992

Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in WB,IHC,FCM,IP,ICC,IF.

Anti-p53 Antibody (5M213)

Anti-p53 Antibody (5M213)

😃Good
Catalog No. TMAC-02992
Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in WB,IHC,FCM,IP,ICC,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-p53 Antibody (5M213) is a Rabbit antibody targeting p53. Anti-p53 Antibody (5M213) can be used in WB,IHC,FCM,IP,ICC,IF.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:500; IHC: 1:100; ICC: 1:100-500; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundActs as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 53 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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