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360A
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Catalog No. T7409Cas No. 794458-56-3
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
360A
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Purity: 98.68%
Catalog No. T7409Cas No. 794458-56-3
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $97 | In Stock | In Stock | |
| 2 mg | $153 | In Stock | In Stock | |
| 5 mg | $221 | In Stock | In Stock | |
| 10 mg | $337 | In Stock | In Stock | |
| 25 mg | $558 | In Stock | In Stock | |
| 50 mg | $785 | - | In Stock | |
| 100 mg | $1,120 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.68%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM). |
| Targets&IC50 | Telomerase:300 nM |
| In vitro | A549 lung carcinoma cell lines treatment with 5 μM of 360A led to an inhibition of cell proliferation within 11 days of treatmen. Treatment with the newly synthesized dimer (360A)2A led to a comparable antiproliferative effect[1] |
| Cell Research | Supplemented with 10% fetal calf serum (FCS) and 1% penicillin/streptomycin. A549 cells were maintained in humidified incubators at 37 °C in an atmosphere containing 5% CO2 and ambient oxygen of 20%. Cells were grown in 25 cm^2 flasks (150,000 cells/flask) and treated with 5 μM of 360A or (360A)2A every 3 or 4 days (i.e., at each reseeding) until cultures were terminated. Control cells were either non-treated or treated with 0.1% DMSO. At each reseeding the remaining cells were pelleted and snap frozen for further DNA extraction.Statistical analysis was performed using GraphPad Prism 5. A Chi-square test was used to compare TDEs frequencies[1]. |
| Molecular Weight | 449.5 |
| Formula | C27H23N5O2 |
| Cas No. | 794458-56-3 |
| Smiles | C[N+]=1C2=C(C=C(NC(=O)C=3N=C(C(NC4=CC5=C([N+](C)=C4)C=CC=C5)=O)C=CC3)C1)C=CC=C2 |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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