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Polymyxin B nonapeptide

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Catalog No. TP1341Cas No. 86408-36-8

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)

Polymyxin B nonapeptide
Other Forms of Polymyxin B nonapeptide:

Polymyxin B nonapeptide

😃Good
Catalog No. TP1341Cas No. 86408-36-8
Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$121InquiryInquiry
10 mg$207InquiryInquiry
50 mg$783InquiryInquiry
100 mg$1,190InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)
Chemical Properties
Molecular Weight963.13
FormulaC43H74N14O11
Cas No.86408-36-8
SmilesC([C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCN)C(=O)N[C@@H](CCN)C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC[C@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CCN)=O)C(=O)N[C@@H](CCN)C(=O)N1)[H])C2=CC=CC=C2
Relative Density.1.32 g/cm3 at 20℃ (Predicted)
SequenceThr-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)
Sequence ShortT-{Dab}-{Dab}-{Dab}-d-FL-{Dab}-{Dab}-T (Lactam: Dab3-Thr9)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 100 mg/mL (103.83 mM), Sonication is recommended.
DMSO: 16.67 mg/mL (17.31 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM1.0383 mL5.1914 mL10.3828 mL51.9141 mL
5 mM0.2077 mL1.0383 mL2.0766 mL10.3828 mL
10 mM0.1038 mL0.5191 mL1.0383 mL5.1914 mL
H2O
1mg5mg10mg50mg
20 mM0.0519 mL0.2596 mL0.5191 mL2.5957 mL
50 mM0.0208 mL0.1038 mL0.2077 mL1.0383 mL
100 mM0.0104 mL0.0519 mL0.1038 mL0.5191 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Polymyxin B nonapeptide
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