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Fosfomycin sodium

Name: Fosfomycin sodium
Brand: TargetMol
SKU: T8262
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8262Cas No. 26016-99-9

Alias Fosfomycin Disodium

Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.

Fosfomycin sodium

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Purity: 99.63%

Catalog No. T8262Alias Fosfomycin DisodiumCas No. 26016-99-9

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$56	-	In Stock
5 g	$98	-	In Stock
10 g	$139	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Potency:≥700IU

Color:White

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COA LCMS HNMR

Product Introduction

Fosfomycin sodium AI Summary

Fosfomycin sodium demonstrates notable antifilarial and antimicrobial properties. It exhibits robust antifilarial activity against Molinema dessetae, both in vivo and in vitro, with effective dosages of 1000 mg/kg administered subcutaneously once daily for 5 days to the infected host Proechimys oris. In vitro, the compound requires concentrations greater than 500,000 nM to kill 50% of infective larvae after 7 days. Moreover, it shows significant antibacterial activity against a variety of bacterial strains including methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Ralstonia solanacearum, and Escherichia coli, with MIC values ranging from 1.95 to 125.0 µg/mL. Specifically, it inhibits Escherichia coli BL21(DE3) with a MIC of 20.0 µg/mL and displays inhibition of Candida albicans Fructose-1,6-Bisphosphate Aldolase with a 0.32% inhibition at 50 µM. Additionally, Fosfomycin sodium shows efficacy in various bioassays, acting as an inhibitor with significant potencies against AmpC Beta-Lactamase (5623.4 nM), JMJD2A-Tudor Domain (100000.0 nM), and the RanGTP-induced Rango-Importin beta complex dissociation (7307.8 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.
Synonyms	Fosfomycin Disodium

Chemical Properties

Molecular Weight	182.02
Formula	C₃H₅Na₂O₄P
Cas No.	26016-99-9
Smiles	[Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 36 mg/mL (197.78 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.4939 mL	27.4695 mL	54.9390 mL	274.6951 mL
5 mM	1.0988 mL	5.4939 mL	10.9878 mL	54.9390 mL
10 mM	0.5494 mL	2.7470 mL	5.4939 mL	27.4695 mL
20 mM	0.2747 mL	1.3735 mL	2.7470 mL	13.7348 mL
50 mM	0.1099 mL	0.5494 mL	1.0988 mL	5.4939 mL
100 mM	0.0549 mL	0.2747 mL	0.5494 mL	2.7470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc