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Buprofezin
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Catalog No. T3496Cas No. 69327-76-0
Alias NNI 750, Buprofezine, Applaud
Buprofezin (Applaud) is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.
Buprofezin
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Purity: 99.73%
Catalog No. T3496Alias NNI 750, Buprofezine, ApplaudCas No. 69327-76-0
Buprofezin (Applaud) is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $46 | In Stock | In Stock | |
| 200 mg | $65 | In Stock | In Stock | |
| 500 mg | $107 | - | In Stock | |
| 1 g | $159 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.73%
Appearance:Solid
Color:White
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Product Introduction
Buprofezin AI Summary
Buprofezin exhibits a wide range of bioactivities and significant insecticidal properties. It functions as an estrogen receptor alpha agonist while acting as an antagonist for thyroid hormone receptor beta, farnesoid X receptor, androgen receptor, peroxisome proliferator-activated receptor gamma, and retinoid X receptor alpha signaling pathways. Additionally, it activates peroxisome proliferator-activated receptor delta, peroxisome proliferator-activated receptor gamma, vitamin D receptor, antioxidant response element (ARE), and human pregnane X receptor (PXR) signaling pathways.
In terms of insecticidal activity, Buprofezin is highly effective against Bemisia tabaci (sweet potato whitefly), showing potency across various life stages by affecting offspring sex ratio, longevity, and egg hatch rate, with higher concentrations yielding greater mortality rates. It is also efficacious against various hybrids, generations, and buprofezin-resistant populations of Bemisia tabaci.
The compound demonstrates significant insecticidal effectiveness against Encarsia inaron, particularly when applied to larval stages at 31.25 ppm, reducing sex ratio, egg-laying rate, and longevity. When applied to cucumber plants infested with Encarsia inaron, it reduces adult parasitoid emergence, especially at pupal stages.
Noteworthy is its acute toxicity observed in female adult Anagrus nilaparvatae, with 29.4% mortality from oral administration and minimal residual toxicity (1.1%) from compound-treated rice leaves. Its acute contact toxicity LC50 for adult Anagrus nilaparvatae is above 1000.0 mgAi/L, indicating relatively low contact toxicity.
Buprofezin also shows substantial activity against first-instar larvae of Cheumatopsyche brevilineata with an EC50 value of 0.181 ug/mL and demonstrates a lower, yet notable, toxicity towards Daphnia magna. The compound has a high partition coefficient (log KOW of 4.3), indicating good solubility in both water and organic phases.
Furthermore, the compound affects Nilaparvata lugens (brown planthopper) by impacting lifespan, ovariole development, egg maturity, hatchability, and oviposition. It induces mortality in brown planthopper adults and fifth-instar nymphs in a concentration-dependent manner over 7 days of exposure..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Buprofezin (Applaud) is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops. |
| Synonyms | NNI 750, Buprofezine, Applaud |
| Molecular Weight | 305.44 |
| Formula | C16H23N3OS |
| Cas No. | 69327-76-0 |
| Smiles | C(C)(C)N1C(=NC(C)(C)C)SCN(C1=O)C2=CC=CC=C2 |
| Relative Density. | 1.18 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (163.7 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.55 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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