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Cimetidine hydrochloride

Catalog No. T60584 CAS 70059-30-2

Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride shows anti-cancer and anti-inflammatory activity. Cimetidine hydrochloride is a gastric acid reducer that can be used in the research of duodenal and gastric ulcers[1] [2] [5].

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Cimetidine hydrochloride Chemical Structure

Cimetidine hydrochloride, CAS 70059-30-2

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride shows anti-cancer and anti-inflammatory activity. Cimetidine hydrochloride is a gastric acid reducer that can be used in the research of duodenal and gastric ulcers[1] [2] [5].
In vitro	Cimetidine (SKF-92334) hydrochloride, distinguished as a partial H2R agonist, exhibits a unique pharmacological profile compared to ranitidine and famotidine, which may underlie its anticancer effects on gastrointestinal malignancies [1]. In ovarian cancer cells expressing high OCT2 mRNA levels (IGROV-1 cells), cimetidine hydrochloride does not affect cisplatin's uptake or cytotoxicity [3]. Additionally, it does not influence the proliferation, survival, migration, or invasion of 3LL cells. However, cimetidine hydrochloride can counteract MDSC-mediated T-cell suppression and enhance IFN-γ production [4]. Its mechanism includes the suppression of NCAM gene expression through inhibiting NF-kappaB nuclear translocation, a key activator of NCAM [5].
In vivo	Cimetidine (SKF-92334) hydrochloride effectively diminishes the accumulation of CD11b(+)Gr-1(+) myeloid derived-suppressive cells (MDSC) in the spleen, blood, and tumor tissues of mice with tumors [4]. Additionally, this compound positively influences periodontal disease in rats by lowering the RANKL/OPG ratio in gingival connective tissue and mitigating alveolar bone resorption [6].

Molecular Weight	288.8
Formula	C10H17ClN6S
CAS No.	70059-30-2

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

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Cimetidine hydrochloride 70059-30-2 inhibitor inhibit

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