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Anti-Angiopoietin 4 Polyclonal Antibody
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Catalog No. TMAB-02546
Anti-Angiopoietin 4 Polyclonal Antibody is a Rabbit antibody targeting Angiopoietin 4. Anti-Angiopoietin 4 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Angiopoietin 4 Polyclonal Antibody
Anti-Angiopoietin 4 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-02546
Anti-Angiopoietin 4 Polyclonal Antibody is a Rabbit antibody targeting Angiopoietin 4. Anti-Angiopoietin 4 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Bioactivity
Antigen Details
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| Description | Anti-Angiopoietin 4 Polyclonal Antibody is a Rabbit antibody targeting Angiopoietin 4. Anti-Angiopoietin 4 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | Tissue/cell: mouse tumor tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-ANGPT3/ANG3/ANGPT4/ANG4 Polyclonal Antibody, Unconjugated (TMAB-02546) 1: 200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted (Probable). |
| Tissue Specificity | Highly expressed in the lung with much lower levels found in other tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Angiopoietin 4 is a glycosylated protein with a fibrinogen C terminal domain. It is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. Angiopoietin 4 is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. It may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described |
| Immunogen | KLH conjugated synthetic peptide: human ANGPT4 |
| Antigen Species | Human |
| Gene Name | ANGPT4 |
| Gene ID | |
| Protein Name | Angiopoietin-4 |
| Uniprot ID | |
| Function | Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. |
| Molecular Weight | Theoretical: 54 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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