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(20R)-Protopanaxadiol

Name: (20R)-Protopanaxadiol
Brand: TargetMol
SKU: T3S1513
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S1513Cas No. 7755-01-3

Alias Protopanaxadiol, 20R-Protopanaxadiol, (20R)-Protopanaxdiol

1. (20R)-Protopanaxadiol ((20R)-Protopanaxdiol) has the effect of anti-tumor through increasing the activity of body immunity, inhibiting tumor interstitial microvascular density and its proliferation activity, improving the lymphocyte transformation, the activity of NK cells and the contents of IL-2 significantly. 2. (20R)-Protopanaxadiol prevents and heals obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.

(20R)-Protopanaxadiol

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Purity: 99.97%

Catalog No. T3S1513Alias Protopanaxadiol, 20R-Protopanaxadiol, (20R)-ProtopanaxdiolCas No. 7755-01-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	In Stock	In Stock
5 mg	$54	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$123	In Stock	In Stock
50 mg	$179	In Stock	-
100 mg	$266	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$61	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

(20R)-Protopanaxadiol AI Summary

(20R)-Protopanaxadiol has been found to exhibit inhibitory activity in an in vitro assay targeting rat liver Acyl coenzyme A:cholesterol acyltransferase, with an IC50 value of 10,000.0 nM. It also demonstrates cytotoxicity against human HL60 and HepG2 cells, with IC50 values of 23,420.0 nM and 69,070.0 nM, respectively, as determined by MTT assay after 48 hours. Additionally, (20R)-Protopanaxadiol shows dose-dependent activation of human CK-MM enzyme activity, achieving the highest increase at 20 µM, although bioactivity decreases at higher concentrations, indicating a potential optimal dosage for maximal enzyme activation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Protopanaxadiol, 20R-Protopanaxadiol, (20R)-Protopanaxdiol

Chemical Properties

Molecular Weight	460.73
Formula	C₃₀H₅₂O₃
Cas No.	7755-01-3
Smiles	CC(C)=CCC[C@@](C)(O)[C@H]1CC[C@@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C
Relative Density.	1.036 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (21.7 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (2.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1705 mL	10.8523 mL	21.7047 mL	108.5234 mL
5 mM	0.4341 mL	2.1705 mL	4.3409 mL	21.7047 mL
10 mM	0.2170 mL	1.0852 mL	2.1705 mL	10.8523 mL
20 mM	0.1085 mL	0.5426 mL	1.0852 mL	5.4262 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc