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9-Methoxycamptothecin

🥰Excellent
Catalog No. T5S1952Cas No. 39026-92-1

9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.

9-Methoxycamptothecin

9-Methoxycamptothecin

🥰Excellent
Purity: 99.56%
Catalog No. T5S1952Cas No. 39026-92-1
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$48-In Stock
50 mg$72-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.56%
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Product Introduction

Bioactivity
Description
9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
In vitro
9-Methoxycamptothecin(MCPT) induced cytotoxicity in seven human cancer cell lines in a dose dependent manner after 72h, with A2780 and Hela cell lines more sensitive, so the two cell lines were chosen to do further studies. MCPT induced strong G2/M arrest in both A2780 cells and Hela cells after 24h, following by substantial sub-G1 arrest (indicating apoptosis). The apoptosis was verified by staining with Annexin V-FITC and propidium iodide. ROS generation increased significantly in MCPT-induced apoptosis. Meanwhile, the apoptosis appeared to be dependent on caspase-3, -8 and -9 in A2780 cells, and caspase-3 in Hela cells. In addition, MCPT induced up-regulation expression of most of seventeen genes in both cell lines. Western blot verified that changes of TNFα, Fas, P53 and P27 protein level were consistent with their gene expression changes[1].
Chemical Properties
Molecular Weight378.38
FormulaC21H18N2O5
Cas No.39026-92-1
SmilesCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cccc(OC)c4cc3Cn1c2=O
Relative Density.1.5g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (132.14 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 1 mg/mL (2.64 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6428 mL13.2142 mL26.4285 mL132.1423 mL
5 mM0.5286 mL2.6428 mL5.2857 mL26.4285 mL
10 mM0.2643 mL1.3214 mL2.6428 mL13.2142 mL
20 mM0.1321 mL0.6607 mL1.3214 mL6.6071 mL
50 mM0.0529 mL0.2643 mL0.5286 mL2.6428 mL
100 mM0.0264 mL0.1321 mL0.2643 mL1.3214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TopoisomeraseInhibitorinhibitApoptosis9-Methoxycamptothecin9Methoxycamptothecin9 Methoxycamptothecin
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