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(E/Z)-GO289

🥰Excellent
Catalog No. T9356Cas No. 694522-87-7

(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.

(E/Z)-GO289

(E/Z)-GO289

🥰Excellent
Purity: 98.1%
Catalog No. T9356Cas No. 694522-87-7
(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$31In StockIn Stock
5 mg$51In StockIn Stock
10 mg$83In StockIn Stock
25 mg$188In StockIn Stock
50 mg$277In StockIn Stock
100 mg$393In StockIn Stock
200 mg$536In StockIn Stock
1 mL x 10 mM (in DMSO)$52In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.1%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.
Chemical Properties
Molecular Weight419.3
FormulaC17H15BrN4O2S
Cas No.694522-87-7
SmilesCOc1cc(\C=N\n2c(SC)nnc2-c2ccccc2)c(Br)cc1O
Relative Density.1.52 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 8.13 mg/mL (19.39 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 0.5 mg/mL (1.19 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3849 mL11.9246 mL23.8493 mL119.2464 mL
5 mM0.4770 mL2.3849 mL4.7699 mL23.8493 mL
10 mM0.2385 mL1.1925 mL2.3849 mL11.9246 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

rhythmsphosphorylationInhibitorinhibitgrowthclockCK2circadiancellCaseinKinaseCasein Kinasecancer(E/Z)-GO-289(E/Z)-GO289(E/Z)GO289(E/Z)-GO 289(E/Z) GO289
Related Tags: buy (E/Z)-GO289 | purchase (E/Z)-GO289 | (E/Z)-GO289 cost | order (E/Z)-GO289 | (E/Z)-GO289 chemical structure | (E/Z)-GO289 formula | (E/Z)-GO289 molecular weight
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