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L-Kynurenine

Name: L-Kynurenine
Brand: TargetMol
SKU: T4928
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4928Cas No. 2922-83-0

Alias (S)-Kynurenine

L-Kynurenine ((S)-Kynurenine) is an endogenous agonist of the tryptophan metabolite and the aromatic hydrocarbon receptor (AHR). L-Kynurenine can inhibit the proliferation of allogeneic T cells and increase the invasion of malignant U87 glioma cells into the collagen matrix.

L-Kynurenine

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Purity: 99.91%

Catalog No. T4928Alias (S)-KynurenineCas No. 2922-83-0

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$40	In Stock	In Stock
100 mg	$56	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.91%

Color:White to Yellow

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Product Introduction

Bioactivity

Description	L-Kynurenine ((S)-Kynurenine) is an endogenous agonist of the tryptophan metabolite and the aromatic hydrocarbon receptor (AHR). L-Kynurenine can inhibit the proliferation of allogeneic T cells and increase the invasion of malignant U87 glioma cells into the collagen matrix.
Targets&IC50	GABAA (pentobarbital stimulation of [3H]flunitrazepam binding):35.9 ± 14.8 μM, B16 F10 melanoma cells:1.74 mM
In vitro	METHODS: Human corneal endothelial cells (HCEC) were treated with L-Kynurenine (10-40 µM), and apoptosis of HCECs was evaluated by flow cytometry using fluorescent isothiocyanate Annexin-V conjugates (FITC). RESULTS: L-Kynurenine-induced apoptosis slightly increased. [1] METHODS: NK92 MI cells were treated with L-Kynurenine (0-800 μM) for 72 hours. Cell viability was evaluated by trypan blue staining, and flow cytometry analysis or functional detection was performed. RESULTS: L-Kynurenine dose-dependently induced cell growth inhibition and apoptosis. [2]
In vivo	METHODS: To study the effect of L-Kynurenine on arteries, L-Kynurenine was administered to the mesenteric arteries (0.3 mM to 1 mM) and aorta (1 mM to 1 mM) of male Wistar rats. RESULTS: L-Kynurenine induced concentration-dependent diastolic responses in the mesenteric arteries and aorta of rats, while the selective Kv7 inhibitor aspirin and the depolarizing agent potassium chloride eliminated this diastolic effect. [3] METHODS: To study the neuroprotective effect of L-Kynurenine, L-Kynurenine (50-300 mg/kg) was intraperitoneally injected into neonatal rats. One hour after intraperitoneal injection, the young rats were exposed to a hypoxic environment for 1.5 hours to construct a hypoxia-ischemia neonatal rat model. L-Kynurenine (100, 200, 3000, 400 mg/kg) was intraperitoneally injected into neonatal rats. One hour after intraperitoneal injection, NMDA was injected to construct the neonatal rat model of NMDA injury. RESULTS: L-Kynurenine demonstrated a dose-dependent significant neuroprotective effect and had a complete protective effect at a dose of 300 mg/kg. [4]
Synonyms	(S)-Kynurenine

Chemical Properties

Molecular Weight	208.21
Formula	C₁₀H₁₂N₂O₃
Cas No.	2922-83-0
Smiles	N[C@@H](CC(=O)c1ccccc1N)C(O)=O
Relative Density.	1.343 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (240.14 mM), Sonication is recommended.

H2O: 4 mg/mL (19.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (4.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8028 mL	24.0142 mL	48.0284 mL	240.1422 mL
5 mM	0.9606 mL	4.8028 mL	9.6057 mL	48.0284 mL
10 mM	0.4803 mL	2.4014 mL	4.8028 mL	24.0142 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2401 mL	1.2007 mL	2.4014 mL	12.0071 mL
50 mM	0.0961 mL	0.4803 mL	0.9606 mL	4.8028 mL
100 mM	0.0480 mL	0.2401 mL	0.4803 mL	2.4014 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc