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Anti-S100A8 Antibody-PE (7D796)
🥰Excellent
Catalog No. TMAY-01676P
Anti-S100A8 Antibody-PE (7D796) is a PE-conjugated Mouse antibody targeting S100A8. Anti-S100A8 Antibody-PE (7D796) can be used in FCM.
Anti-S100A8 Antibody-PE (7D796)
Anti-S100A8 Antibody-PE (7D796)
🥰Excellent
Catalog No. TMAY-01676P
Anti-S100A8 Antibody-PE (7D796) is a PE-conjugated Mouse antibody targeting S100A8. Anti-S100A8 Antibody-PE (7D796) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-S100A8 Antibody-PE (7D796) is a PE-conjugated Mouse antibody targeting S100A8. Anti-S100A8 Antibody-PE (7D796) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 7D796 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human S100A8 expression on human whole blood Granulocytes. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with PE-conjugated anti-Human S100A8. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable Granulocytes. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human S100A8 (rh S100A8; TMPY-01356; NP_002955.2; Met1-Glu93) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and cancer suggest that S100A8/A9 may play a key role in inflammation-associated cancer. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human S100A8 Protein (TMPY-01356) |
| Antigen Species | Human |
| Biology Area | Calcium-binding Proteins and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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