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Anthraquinone
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Catalog No. TMO2787Cas No. 84-65-1
Alias dioxoanthracene, Anthradione, anthracenedione
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.
Anthraquinone
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Purity: 98.93%
Catalog No. TMO2787Alias dioxoanthracene, Anthradione, anthracenedioneCas No. 84-65-1
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 g | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.93%
Appearance:Solid
Color:Yellow
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Product Introduction
Anthraquinone AI Summary
Anthraquinone displays a diverse range of bioactivities across various biological systems and targets. It enhances the proliferation of MCF-7 cell line at concentrations of 1 uM, 3 uM, and 10 uM, showing control rates of 112.7%, 109.8%, and 114.0%, respectively. It demonstrates in vitro inhibitory activity against Plasmodium falciparum D6 with an IC50 of 5000.0 nM and shows significant antiproliferative effects against human A2780 cells with an IC50 of 580.0 nM. However, its inhibition of histidine-tagged human recombinant Cdc25B, mouse MKP1, and rat MKP3 catalytic domains is less potent, with IC50 values above 50000.0 nM.
The compound inhibits lipid peroxidation in Sprague-Dawley rat heart mitochondria, indicating potential antioxidant properties, and inhibits the activation of EBV-early antigen in human Raji cells with a logIC50 of 3.04. It also shows significant activity in inhibiting Menin-MLL interaction and identifying anesthetics, retinoid X receptor alpha signaling agonists, malarial parasite inhibitors, and estrogen receptor alpha antagonists. Notably, it shows low cytotoxicity against various human cell lines (HL60, J82, SKMES1, AGS, and MRC5).
Anthraquinone inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells, with inhibition percentages of 96.98% and 78.8%, respectively. It also modulates the activity of histone lysine methyltransferases (GLP and G9a) and HDAC6 enzymatic activity. Furthermore, it demonstrates antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells, though with varying inhibition rates.
Lastly, Anthraquinone shows bioactivity as an inhibitor of recombinant human MAO-A, with an IC50 value of 122000.0 nM, and exhibits moderate inhibitory activity against PDK4 and potential phytotoxicity and antifungal properties. It shows no significant activity against N-methyl-D-aspartate glutamate receptors and lower inhibition rates for SARS-CoV-2 3CL-Pro protease at higher concentrations..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation. |
| Synonyms | dioxoanthracene, Anthradione, anthracenedione |
| Molecular Weight | 208.21 |
| Formula | C14H8O2 |
| Cas No. | 84-65-1 |
| Smiles | O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2 |
| Relative Density. | 1.438. |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble)  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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