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Anthraquinone (Alias: dioxoanthracene, Anthradione, anthracenedione)

Catalog No. TMO2787 Copy Product Info
Purity: 98.93%
🥰Excellent
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.

Anthraquinone

Copy Product Info
🥰Excellent
Catalog No. TMO2787
Alias dioxoanthracene, Anthradione, anthracenedione

Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.

Anthraquinone
Cas No. 84-65-1
Pack SizePriceUSA StockGlobal StockQuantity
5 g$29-In Stock
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.93%
Appearance:Solid
Color:Yellow
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Product Introduction

Anthraquinone AI Summary
Anthraquinone displays a diverse range of bioactivities across various biological systems and targets. It enhances the proliferation of MCF-7 cell line at concentrations of 1 uM, 3 uM, and 10 uM, showing control rates of 112.7%, 109.8%, and 114.0%, respectively. It demonstrates in vitro inhibitory activity against Plasmodium falciparum D6 with an IC50 of 5000.0 nM and shows significant antiproliferative effects against human A2780 cells with an IC50 of 580.0 nM. However, its inhibition of histidine-tagged human recombinant Cdc25B, mouse MKP1, and rat MKP3 catalytic domains is less potent, with IC50 values above 50000.0 nM. The compound inhibits lipid peroxidation in Sprague-Dawley rat heart mitochondria, indicating potential antioxidant properties, and inhibits the activation of EBV-early antigen in human Raji cells with a logIC50 of 3.04. It also shows significant activity in inhibiting Menin-MLL interaction and identifying anesthetics, retinoid X receptor alpha signaling agonists, malarial parasite inhibitors, and estrogen receptor alpha antagonists. Notably, it shows low cytotoxicity against various human cell lines (HL60, J82, SKMES1, AGS, and MRC5). Anthraquinone inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells, with inhibition percentages of 96.98% and 78.8%, respectively. It also modulates the activity of histone lysine methyltransferases (GLP and G9a) and HDAC6 enzymatic activity. Furthermore, it demonstrates antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells, though with varying inhibition rates. Lastly, Anthraquinone shows bioactivity as an inhibitor of recombinant human MAO-A, with an IC50 value of 122000.0 nM, and exhibits moderate inhibitory activity against PDK4 and potential phytotoxicity and antifungal properties. It shows no significant activity against N-methyl-D-aspartate glutamate receptors and lower inhibition rates for SARS-CoV-2 3CL-Pro protease at higher concentrations..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.
Synonymsdioxoanthracene, Anthradione, anthracenedione
Chemical Properties
Molecular Weight208.21
FormulaC14H8O2
Cas No.84-65-1
SmilesO=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2
Relative Density.1.438.
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1 mg/mL (insoluble or slightly soluble)

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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