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mTOR inhibitor-8

🥰Excellent
Catalog No. T36316Cas No. 2489196-70-3
Alias mTOR-IN-8

mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.

mTOR inhibitor-8

mTOR inhibitor-8

🥰Excellent
Purity: 98.11%
Catalog No. T36316Alias mTOR-IN-8Cas No. 2489196-70-3
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$48In StockIn Stock
5 mg$113In StockIn Stock
10 mg$189In StockIn Stock
25 mg$378In StockIn Stock
50 mg$619In StockIn Stock
100 mg$993In StockIn Stock
1 mL x 10 mM (in DMSO)$118In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.11%
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Product Introduction

Bioactivity
Description
mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.
In vitro
mTOR inhibitor-8 (Compound 5e; 0.1-10 μM) suppresses the growth of A549 cells in a dose-dependent manner after 24 and 48 hours of treatment[1]. At a concentration of 10 μM, mTOR inhibitor-8 induces autophagy in an mTOR-dependent and time-dependent manner (3-24 hours), increasing LC3B-II levels and reducing the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1)[1].
In vivo
In vivo, mTOR inhibitor-8 effectively inhibits tumor growth at concentrations of 25 and 50 μM for a duration of 6 days, without adversely affecting angiogenesis in the normal chick chorioallantoic membrane [1].
SynonymsmTOR-IN-8
Chemical Properties
Molecular Weight446.95
FormulaC24H19ClN4OS
Cas No.2489196-70-3
SmilesCOc1ccc(cc1)C1CC(=NN1c1nc(cs1)-c1ccncc1)c1ccc(Cl)cc1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (44.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 2 mg/mL (4.47 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2374 mL11.1869 mL22.3739 mL111.8693 mL
5 mM0.4475 mL2.2374 mL4.4748 mL22.3739 mL
10 mM0.2237 mL1.1187 mL2.2374 mL11.1869 mL
20 mM0.1119 mL0.5593 mL1.1187 mL5.5935 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

mTOR inhibitor-8mTOR inhibitor8mTOR inhibitor 8mTORAutophagy
Related Tags: buy mTOR inhibitor-8 | purchase mTOR inhibitor-8 | mTOR inhibitor-8 cost | order mTOR inhibitor-8 | mTOR inhibitor-8 chemical structure | mTOR inhibitor-8 in vivo | mTOR inhibitor-8 in vitro | mTOR inhibitor-8 formula | mTOR inhibitor-8 molecular weight
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