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Anti-Phospho-Lck (Tyr505) Polyclonal Antibody (Synonyms: p-Lck (Y505), p-Lck (Tyr505), Lck (p-Y505), Lck (p-T...)
Catalog No. TMAC-02386 Copy Product Info
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Anti-Phospho-Lck (Tyr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Lck (Tyr505). Anti-Phospho-Lck (Tyr505) Polyclonal Antibody can be used in WB.
Anti-Phospho-Lck (Tyr505) Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAC-02386
Synonyms p-Lck (Y505), p-Lck (Tyr505), Lck (p-Y505), Lck (p-Tyr505)
Anti-Phospho-Lck (Tyr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Lck (Tyr505). Anti-Phospho-Lck (Tyr505) Polyclonal Antibody can be used in WB.
Anti-Phospho-Lck
(Tyr505) Polyclonal Antibody
(Tyr505) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $217 | 7-10 days | 7-10 days | |
| 100 μL | $318 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Phospho-Lck (Tyr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Lck (Tyr505). Anti-Phospho-Lck (Tyr505) Polyclonal Antibody can be used in WB. |
| Synonyms | p-Lck (Y505), p-Lck (Tyr505), Lck (p-Y505), Lck (p-Tyr505) |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of extracts from JK cells using Lck (phospho-Tyr505) Antibody TMAC-02386 and the same antibody preincubated with blocking peptide. 2. Western blot analysis of extracts from 293 cells, treated with calf intestinal phosphatase (CIP), using Lck (phospho-Tyr505) Antibody TMAC-02386.   |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature a beta TCR. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 505 (G-Q-Y(p)-Q-P) derived from Human Lck |
| Antigen Species | human |
| Uniprot ID |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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