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Anti-Human Bcl-2 Antibody (6Z4)

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Catalog No. TMAB-07382

Anti-Human Bcl-2 Antibody (6Z4) is a Mouse antibody targeting Human Bcl-2. Anti-Human Bcl-2 Antibody (6Z4) can be used in FCM,ICC/IF.

Anti-Human Bcl-2 Antibody (6Z4)

Anti-Human Bcl-2 Antibody (6Z4)

😃Good
Catalog No. TMAB-07382
Anti-Human Bcl-2 Antibody (6Z4) is a Mouse antibody targeting Human Bcl-2. Anti-Human Bcl-2 Antibody (6Z4) can be used in FCM,ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 μg$3527-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Human Bcl-2 Antibody (6Z4) is a Mouse antibody targeting Human Bcl-2. Anti-Human Bcl-2 Antibody (6Z4) can be used in FCM,ICC/IF.
Ig Type
Mouse IgG2b,k
Clone
6Z4
Reactivity
Human
Application
Recommended Dose
FCM: 1μg/Test; ICC/IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationMitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue SpecificityExpressed in a variety of tissues.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4).
Research BackgroundThe Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).
Antigen Details
Gene Name
BCL2
Gene ID
Protein Name
Apoptosis regulator Bcl-2
Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Chemical Properties
Molecular WeightTheoretical: 26 kDa. Actual: 26 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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