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Senecionine
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Catalog No. TQ0192Cas No. 130-01-8
Alias Senecionin, Senecionan-11,16-dione, 12-hydroxy-, Aureine
Cytidine 5'-triphosphate disodium salt is one of the endogenous metabolites and is a cation-permeable ligand-gated ion channel agonist.
Senecionine
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Purity: 99.96%
Catalog No. TQ0192Alias Senecionin, Senecionan-11,16-dione, 12-hydroxy-, AureineCas No. 130-01-8
Cytidine 5'-triphosphate disodium salt is one of the endogenous metabolites and is a cation-permeable ligand-gated ion channel agonist.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $60 | In Stock | In Stock | |
| 5 mg | $152 | In Stock | In Stock | |
| 10 mg | $247 | In Stock | In Stock | |
| 25 mg | $418 | In Stock | In Stock | |
| 50 mg | $595 | In Stock | In Stock | |
| 100 mg | $862 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Cytidine 5'-triphosphate disodium salt is one of the endogenous metabolites and is a cation-permeable ligand-gated ion channel agonist. |
| In vitro | The cytotoxicity was greater in the absence of extracellular Ca2+ than in its presence, suggesting that alterations in intracellular Ca2+ distribution, and not an influx of extracellular Ca2+, were responsible for the Senecionine-induced hepatotoxicity [1]. |
| In vivo | Senecionine fails to stimulate epoxide hydrase, it diminishes the activity of glutathione-s-transferase, aminopyrine demethylase and AHH [2]. Twice-weekly injections of senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth [3]. |
| Animal Research | Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4) [4]. |
| Synonyms | Senecionin, Senecionan-11,16-dione, 12-hydroxy-, Aureine |
| Molecular Weight | 335.39 |
| Formula | C18H25NO5 |
| Cas No. | 130-01-8 |
| Smiles | C\C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23 |
| Relative Density. | 1.255g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | Ethanol: 1 mg/mL (2.98 mM), Sonication is recommended. DMSO: 1.68 mg/mL (5.01 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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