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Saikogenin A

Name: Saikogenin A
Brand: TargetMol
SKU: T16838
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16838Cas No. 5092-09-1

Saikogenin A is a dipeptidyl peptidase-4 inhibitor.

Saikogenin A

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Purity: 99.47%

Catalog No. T16838Cas No. 5092-09-1

Saikogenin A is a dipeptidyl peptidase-4 inhibitor.

Pack Size	Price	Availability
1 mg	$198	In Stock
5 mg	$513	In Stock
10 mg	$819	In Stock
25 mg	$1,220	In Stock
50 mg	$1,630	In Stock
100 mg	$2,220	Backorder
1 mL x 10 mM (in DMSO)	$588	In Stock

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Batch Information

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Purity:99.47%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Saikogenin A is a dipeptidyl peptidase-4 inhibitor.
In vitro	Saikogenin A has a certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6% [1].
In vivo	Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A is due to an increase in corticosterone caused by the release of arenocorticotropic hormone and a direct effect on the process of inflammation [2].

Chemical Properties

Molecular Weight	472.7
Formula	C₃₀H₄₈O₄
Cas No.	5092-09-1
Smiles	[H][C@@]12CC[C@]3(C)[C@]([H])(C=CC4=C5CC(C)(C)CC[C@]5(CO)[C@@H](O)C[C@@]34C)[C@@]1(C)CC[C@H](O)[C@@]2(C)CO
Relative Density.	1.16 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (126.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1155 mL	10.5775 mL	21.1551 mL	105.7753 mL
5 mM	0.4231 mL	2.1155 mL	4.2310 mL	21.1551 mL
10 mM	0.2116 mL	1.0578 mL	2.1155 mL	10.5775 mL
20 mM	0.1058 mL	0.5289 mL	1.0578 mL	5.2888 mL
50 mM	0.0423 mL	0.2116 mL	0.4231 mL	2.1155 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc