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Anti-DC-SIGN Antibody-APC (8Q432)
🥰Excellent
Catalog No. TMAY-00445A
Anti-DC-SIGN Antibody-APC (8Q432) is a APC-conjugated Mouse antibody targeting DC-SIGN. Anti-DC-SIGN Antibody-APC (8Q432) can be used in FCM.
Anti-DC-SIGN Antibody-APC (8Q432)
Anti-DC-SIGN Antibody-APC (8Q432)
🥰Excellent
Catalog No. TMAY-00445A
Anti-DC-SIGN Antibody-APC (8Q432) is a APC-conjugated Mouse antibody targeting DC-SIGN. Anti-DC-SIGN Antibody-APC (8Q432) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-DC-SIGN Antibody-APC (8Q432) is a APC-conjugated Mouse antibody targeting DC-SIGN. Anti-DC-SIGN Antibody-APC (8Q432) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8Q432 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with APC-conjugated anti-Human CD209. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD209/DC-SIGN (rh CD209/DC-SIGN; TMPY-00772; NP_066978.1; Lys62-Ala404) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human CD209/DC-SIGN Protein (TMPY-00772) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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