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PFI-2 hydrochloride

Name: PFI-2 hydrochloride
Brand: TargetMol
SKU: T4583
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4583Cas No. 1627607-87-7

Alias PFI-2 HCl, (R)-PFI-2 hydrochloride

PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.

PFI-2 hydrochloride

🥰Excellent

Purity: 99.91%

Catalog No. T4583Alias PFI-2 HCl, (R)-PFI-2 hydrochlorideCas No. 1627607-87-7

PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$47	In Stock
5 mg	$77	In Stock
10 mg	$119	In Stock
25 mg	$223	In Stock
50 mg	$397	In Stock
100 mg	$582	In Stock
500 mg	$1,230	In Stock
1 mL x 10 mM (in DMSO)	$130	In Stock

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Purity:99.91%

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Product Introduction

Bioactivity

Description	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.
Targets&IC50	SETD7:2 nM
In vitro	(R)-PFI-2 is highly selective (>1,000-fold) for SETD7, over a panel of 18 other human protein methyltransferases and DNMT1, and was shown to be inactive against 134 additional ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). (R)-PFI-2 binds to SETD7 only in the presence of SAM. PFI-766, a biotinylated variant of (R)-PFI-2 that retains the ability to bind and inhibit SETD7 (IC50 110 ± 26 nM in our in vitro enzymatic assay).
Synonyms	PFI-2 HCl, (R)-PFI-2 hydrochloride

Chemical Properties

Molecular Weight	535.98
Formula	C₂₃H₂₆ClF₄N₃O₃S
Cas No.	1627607-87-7
Smiles	Cl.Fc1cc(cc2CCNCc12)S(=O)(=O)N[C@H](Cc1cccc(c1)C(F)(F)F)C(=O)N1CCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (102.62 mM), Sonication is recommended.

Ethanol: 10 mg/mL (18.66 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8657 mL	9.3287 mL	18.6574 mL	93.2871 mL
5 mM	0.3731 mL	1.8657 mL	3.7315 mL	18.6574 mL
10 mM	0.1866 mL	0.9329 mL	1.8657 mL	9.3287 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0933 mL	0.4664 mL	0.9329 mL	4.6644 mL
50 mM	0.0373 mL	0.1866 mL	0.3731 mL	1.8657 mL
100 mM	0.0187 mL	0.0933 mL	0.1866 mL	0.9329 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc