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Anti-SIRT6 Antibody (6U297)

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Catalog No. TMAC-03765
Alias SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6

Anti-SIRT6 Antibody (6U297) is a Rabbit antibody targeting SIRT6. Anti-SIRT6 Antibody (6U297) can be used in WB,ICC/IF,FCM.

Anti-SIRT6 Antibody (6U297)

Anti-SIRT6 Antibody (6U297)

😃Good
Catalog No. TMAC-03765Alias SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6
Anti-SIRT6 Antibody (6U297) is a Rabbit antibody targeting SIRT6. Anti-SIRT6 Antibody (6U297) can be used in WB,ICC/IF,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-SIRT6 Antibody (6U297) is a Rabbit antibody targeting SIRT6. Anti-SIRT6 Antibody (6U297) can be used in WB,ICC/IF,FCM.
AliasSIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:1000; ICC/IF: 1:50-200; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 39 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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