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Anti-SIRT6 Antibody (6U297)
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Catalog No. TMAC-03765
Alias SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6
Anti-SIRT6 Antibody (6U297) is a Rabbit antibody targeting SIRT6. Anti-SIRT6 Antibody (6U297) can be used in FCM,ICC/IF,WB.
Anti-SIRT6 Antibody (6U297)
Anti-SIRT6 Antibody (6U297)
😃Good
Catalog No. TMAC-03765Alias SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6
Anti-SIRT6 Antibody (6U297) is a Rabbit antibody targeting SIRT6. Anti-SIRT6 Antibody (6U297) can be used in FCM,ICC/IF,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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Chemical Properties
| Description | Anti-SIRT6 Antibody (6U297) is a Rabbit antibody targeting SIRT6. Anti-SIRT6 Antibody (6U297) can be used in FCM,ICC/IF,WB. |
| Synonyms | SIRT6, SIR2-like protein 6, SIR2L6, Regulatory protein SIR2 homolog 6 (hSIRT6), Protein mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent protein deacylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6 |
| Ig Type | IgG |
| Clone | 6U297 |
| Reactivity | Human |
| Verified Activity | 1. ICC staining SIRT6 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 2. ICC staining SIRT6 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. Flow cytometric analysis of Hela cells with SIRT6 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 39 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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