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H-Val-Pro-Pro-OH

Name: H-Val-Pro-Pro-OH
Brand: TargetMol
SKU: T7354
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7354Cas No. 58872-39-2

H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM).

H-Val-Pro-Pro-OH

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Purity: 98.23%

Catalog No. T7354Cas No. 58872-39-2

H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$143	In Stock	In Stock
100 mg	$209	In Stock	In Stock
200 mg	$313	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.23%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

H-Val-Pro-Pro-OH AI Summary

H-Val-Pro-Pro-OH exhibits a binding affinity against the membrane transport protein PEPT1 in human Caco-2 cells, with a Ki value of 100000 nM. Additionally, it inhibits rabbit lung ACE in a spectrophotometric assay with an IC50 value of 9000 nM. H-Val-Pro-Pro-OH also shows binding affinity to human PepT2 in SKTP cells with a Ki value of approximately 23000 nM, suggesting a potential effect on PepT2 activity or regulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM).
Targets&IC50	ACE:9 μM

Chemical Properties

Molecular Weight	311.38
Formula	C₁₅H₂₅N₃O₄
Cas No.	58872-39-2
Smiles	C(=O)([C@H]1N(C([C@H](C(C)C)N)=O)CCC1)N2[C@H](C(O)=O)CCC2
Relative Density.	1.274 g/cm3 (Predicted)
Sequence	H-Val-Pro-Pro-OH
Sequence Short	VPP

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

H2O: 20 mg/mL (64.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.2115 mL	16.0576 mL	32.1151 mL	160.5755 mL
5 mM	0.6423 mL	3.2115 mL	6.4230 mL	32.1151 mL
10 mM	0.3212 mL	1.6058 mL	3.2115 mL	16.0576 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1606 mL	0.8029 mL	1.6058 mL	8.0288 mL
50 mM	0.0642 mL	0.3212 mL	0.6423 mL	3.2115 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc