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Dehydrocostus Lactone

Name: Dehydrocostus Lactone
Brand: TargetMol
SKU: T2833
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2833Cas No. 477-43-0

Alias Epiligulyl oxide, (-)-Dehydrocostus lactone

Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.

Dehydrocostus Lactone

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🥰Excellent

Purity: 99.98%

Catalog No. T2833Alias Epiligulyl oxide, (-)-Dehydrocostus lactoneCas No. 477-43-0

Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$213	In Stock	In Stock
100 mg	$328	In Stock	In Stock
500 mg	$789	In Stock	-
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Dehydrocostus Lactone AI Summary

Dehydrocostus Lactone shows diverse bioactivities across various biological systems. In ethanol-loaded rats, it effectively reduces blood ethanol levels in a dose-dependent manner, with higher doses leading to significant decreases over time. It inhibits Escherichia coli K12 Mur A and Pseudomonas aeruginosa PAO1293 MurA (IC50 > 50000 nM) and demonstrates antimycobacterial activity against Mycobacterium tuberculosis H37Rv and Mycobacterium avium with MICs of 2.0 and 16.0 µg/mL, respectively. The compound also exhibits antibacterial activity against a range of strains, including vancomycin-resistant Enterococcus and methicillin-resistant Staphylococcus aureus, though with relatively high MICs (> 400 to 800 µg/mL). It shows cytotoxicity against various human cell lines, including OVCAR-3, HeLa, and HepG2, with CD50 values between 2.5 and 3.5 µg/mL, and against leukemia cells with IC50 values ranging from 3700 to 10500 nM. Dehydrocostus Lactone also inhibits CD8+ specific mouse CTL-OE4 cell killing activity (IC50 = 14000 nM) and IL-1-beta-induced ICAM1 expression in human A549 cells (IC50 = 10000 nM), and displays cholinesterase inhibition against electric eel AChE and horse BChE. The compound impacts plant growth variably, showing significant inhibitory and stimulatory effects on root length and germination across different species. It also exhibits gastroprotective and anti-inflammatory activities, antifungal activity against Candida albicans and Cladosporium cucumerinum, and moderate inhibition of c-Myb-induced gene expression in chicken cells with low cytotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.
Synonyms	Epiligulyl oxide, (-)-Dehydrocostus lactone

Chemical Properties

Molecular Weight	230.30
Formula	C₁₅H₁₈O₂
Cas No.	477-43-0
Smiles	C=C1[C@@]2([C@@]3([C@](C(=C)C(=O)O3)(CCC(=C)[C@@]2(CC1)[H])[H])[H])[H]
Relative Density.	1.09

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250.00 mg/mL (1085.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (8.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3422 mL	21.7108 mL	43.4216 mL	217.1081 mL
5 mM	0.8684 mL	4.3422 mL	8.6843 mL	43.4216 mL
10 mM	0.4342 mL	2.1711 mL	4.3422 mL	21.7108 mL
20 mM	0.2171 mL	1.0855 mL	2.1711 mL	10.8554 mL
50 mM	0.0868 mL	0.4342 mL	0.8684 mL	4.3422 mL
100 mM	0.0434 mL	0.2171 mL	0.4342 mL	2.1711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc