Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance. PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
250 μg | 35 days | $ 868.00 | |
1 mg | 35 days | $ 3,120.00 |
Description | Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance. PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg. |
Molecular Weight | 441.47 |
Formula | C24H27NO7 |
CAS No. | 835876-32-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: Soluble
Ethanol: Soluble
DMSO: Soluble
DMF: Soluble
You can also refer to dose conversion for different animals. More
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Platensimycin 835876-32-9 inhibitor inhibit