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GRA Ex-25

Name: GRA Ex-25
Brand: TargetMol
SKU: T3422
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3422Cas No. 307983-31-9

Alias GRA-Ex-25

GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor.

GRA Ex-25

🥰Excellent

Purity: 98.88%

Catalog No. T3422Alias GRA-Ex-25Cas No. 307983-31-9

GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$173	In Stock	In Stock
25 mg	$348	In Stock	In Stock
50 mg	$523	In Stock	In Stock
100 mg	$787	In Stock	In Stock
200 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$139	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.88%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor.
Targets&IC50	Glucagon (human):55 nM, Glucagon (rat):56nM
In vitro	GRA Ex-25 binds to the human glucagon receptor (h-GlucRbind) with a Ki of 63 nM and exhibits moderate glucagon-induced adenylate cyclase inhibition (h-GlucRcyclase) with a Ki of 254 nM under our assay conditions[1], showing similar affinity for both rat and human glucagon receptors (IC50=56 and 55 nM, respectively)[2].
In vivo	GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose induced by exogenous glucagon in rat models, likely through direct inhibition of glucagon-stimulated hepatic glucose output[2].
Synonyms	GRA-Ex-25

Chemical Properties

Molecular Weight	563.61
Formula	C₂₉H₃₆F₃N₃O₅
Cas No.	307983-31-9
Smiles	CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Relative Density.	1.28 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (88.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7743 mL	8.8714 mL	17.7428 mL	88.7138 mL
5 mM	0.3549 mL	1.7743 mL	3.5486 mL	17.7428 mL
10 mM	0.1774 mL	0.8871 mL	1.7743 mL	8.8714 mL
20 mM	0.0887 mL	0.4436 mL	0.8871 mL	4.4357 mL
50 mM	0.0355 mL	0.1774 mL	0.3549 mL	1.7743 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc