Anti-IL-33 Polyclonal Antibody

Name: Anti-IL-33 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00959
Rating: 4.5 (1 reviews)

(Synonyms: NF-HEV, NFEHEV, interleukin 33, IL1F11, DVS27, C9orf26) Copy Product Info

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Synonyms: NF-HEV, NFEHEV, interleukin 33, IL1F11, DVS27, C9orf26

Catalog No. TMAB-00959 Copy Product Info

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Anti-IL-33 Polyclonal Antibody is a Rabbit antibody targeting IL-33. Anti-IL-33 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-IL-33 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-IL-33 Polyclonal Antibody is a Rabbit antibody targeting IL-33. Anti-IL-33 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	NF-HEV, NFEHEV, interleukin 33, IL1F11, DVS27, C9orf26
Ig Type	IgG
Reactivity	Human,Rat

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.
Tissue Specificity	Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	IL33 is a cytokine which belongs to the IL-1 superfamily, and it induces helper T cells to produce type 2 cytokines. This cytokine was previously named NF-HEV 'nuclear factor (NF) in high endothelial venules' (HEVs), as it was originally identified in these specialized cells. IL33 mediates its biological effects by interacting with the receptors ST2 and IL-1 Receptor Accessory Protein, activating intracellular molecules in the NF-kappaB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-4, IL-5 and IL-13) from polarized Th2 cells. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the the severe pathological changes observed in mucosal organs following administration of IL33.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human IL-33 Propeptide
Antigen Species	Human
Gene Name	IL33
Gene ID	90865
Protein Name	Interleukin-33
Uniprot ID	O95760
Biology Area	Cytokines,Hypertrophy,Interleukins
Function	Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.