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Ruscogenin

Name: Ruscogenin
Brand: TargetMol
SKU: T6S1256
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1256Cas No. 472-11-7

1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV34) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. 3. Ruscogenin significantly attenuate LPS-induced acute lung injury via inhibiting expressions of TF and iNOS and NF-kappa B p65 activation.

Ruscogenin

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Purity: 99.87%

Catalog No. T6S1256Cas No. 472-11-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$79	In Stock	In Stock
10 mg	$117	In Stock	In Stock
25 mg	$195	In Stock	In Stock
50 mg	$288	In Stock	In Stock
100 mg	$433	-	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Ruscogenin AI Summary

Ruscogenin exhibits both anticoagulant and anticancer activities. It demonstrates anticoagulant properties by inhibiting TNF-alpha-stimulated tissue factor expression in human THP1 cells, with an IC50 value of 2270.0 nM. Additionally, Ruscogenin reduces cell viability in human BXPC-3 and SW1990 cancer cells, showing IC50 values of 7320.0 nM and 8140.0 nM, respectively, as determined by MTT assay after 48 hours of incubation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	430.62
Formula	C₂₇H₄₂O₄
Cas No.	472-11-7
Smiles	C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)C[C@@H](O)[C@]5(C)[C@H]4CC[C@]23C)O[C@]11CC[C@@H](C)CO1
Relative Density.	1.18 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 78 mg/mL (181.13 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.67 mg/mL (3.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3222 mL	11.6112 mL	23.2223 mL	116.1117 mL
5 mM	0.4644 mL	2.3222 mL	4.6445 mL	23.2223 mL
10 mM	0.2322 mL	1.1611 mL	2.3222 mL	11.6112 mL
20 mM	0.1161 mL	0.5806 mL	1.1611 mL	5.8056 mL
50 mM	0.0464 mL	0.2322 mL	0.4644 mL	2.3222 mL
100 mM	0.0232 mL	0.1161 mL	0.2322 mL	1.1611 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc