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Fumaric acid

Fumaric acid
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
Catalog No. T3763Cas No. 110-17-8
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Purity:99.28%
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Fumaric acid

Catalog No. T3763Cas No. 110-17-8

Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
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Pack SizePriceAvailabilityQuantity
100 g$32In Stock
1 mL x 10 mM (in DMSO)$36In Stock
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Product Introduction

Bioactivity
Description
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
AliasLichenic acid, Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid, Donitic acid, Allomaleic acid
Chemical Properties
Molecular Weight116.07
FormulaC4H4O4
Cas No.110-17-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (473.73 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM8.6155 mL43.0775 mL86.1549 mL430.7745 mL
5 mM1.7231 mL8.6155 mL17.2310 mL86.1549 mL
10 mM0.8615 mL4.3077 mL8.6155 mL43.0775 mL
20 mM0.4308 mL2.1539 mL4.3077 mL21.5387 mL
50 mM0.1723 mL0.8615 mL1.7231 mL8.6155 mL
100 mM0.0862 mL0.4308 mL0.8615 mL4.3077 mL

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