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Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2
Catalog No. TMAB-09252 Copy Product Info
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Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2 is a Rabbit antibody targeting Natriuretic Peptide Receptor A. Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2
Copy Product Info🥰Excellent
Catalog No. TMAB-09252
Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2 is a Rabbit antibody targeting Natriuretic Peptide Receptor A. Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
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| Description | Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2 is a Rabbit antibody targeting Natriuretic Peptide Receptor A. Anti-Natriuretic Peptide Receptor A Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat) |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded Human Duodenum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Natriuretic Peptide Receptor A Polyclonal Antibody, Unconjugated (TMAB-09252) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded Human Gastric Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Natriuretic Peptide Receptor A Polyclonal Antibody, Unconjugated (TMAB-09252) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] |
| Immunogen | KLH conjugated synthetic peptide: human Natriuretic Peptide Receptor A |
| Antigen Species | Human |
| Gene Name | NPR1 |
| Gene ID | |
| Protein Name | Atrial natriuretic peptide receptor 1 |
| Uniprot ID | |
| Function | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. |
| Molecular Weight | Theoretical: 113 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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