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Ganoderic acid D

Name: Ganoderic acid D
Brand: TargetMol
SKU: T5S1133
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S1133Cas No. 108340-60-9

1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 microM.

Ganoderic acid D

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Purity: 99.98%

Catalog No. T5S1133Cas No. 108340-60-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$139	In Stock	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Ganoderic acid D AI Summary

Ganoderic acid D inhibits recombinant human aldose reductase using dl-glyceraldehyde as a substrate, with an IC50 value over 195,300 nM. It exhibits cytotoxicity against human SGC7901, Bel7402, and mouse P388 cells with an IC50 value of 7,250 nM, and against human HeLa cells with IC50 values ranging from 31,000 nM to over 300,000 nM. It also shows weak inhibition of alpha-glucosidase with an IC50 value greater than 600,000 nM. The compound demonstrates a binding affinity to TNF-alpha with a Kd value of 18.6 nM, and anticancer activity against human HepG2 cells, with an IC50 of 22,900 nM. Additionally, it exhibits antiinflammatory activity in mouse BV2 cells by inhibiting LPS-induced nitric oxide production with an IC50 of 10,860 nM and shows a cell viability activity of 93.34% against LPS-induced cytotoxicity in BV2 cells after 24 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	514.65
Formula	C₃₀H₄₂O₇
Cas No.	108340-60-9
Smiles	[H][C@@]12C[C@H](O)C3=C(C(=O)C[C@]4(C)[C@H](CC(=O)[C@@]34C)[C@H](C)CC(=O)CC(C)C(O)=O)[C@@]1(C)CCC(=O)C2(C)C
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9431 mL	9.7153 mL	19.4307 mL	97.1534 mL
5 mM	0.3886 mL	1.9431 mL	3.8861 mL	19.4307 mL
10 mM	0.1943 mL	0.9715 mL	1.9431 mL	9.7153 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc