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Anti-Desmocollin 2/DSC2 Antibody (9D662)
🥰Excellent
Catalog No. TMAY-03795
Anti-Desmocollin 2/DSC2 Antibody (9D662) is a Rabbit antibody targeting Desmocollin 2/DSC2. Anti-Desmocollin 2/DSC2 Antibody (9D662) can be used in IHC-P.
Anti-Desmocollin 2/DSC2 Antibody (9D662)
Anti-Desmocollin 2/DSC2 Antibody (9D662)
🥰Excellent
Catalog No. TMAY-03795
Anti-Desmocollin 2/DSC2 Antibody (9D662) is a Rabbit antibody targeting Desmocollin 2/DSC2. Anti-Desmocollin 2/DSC2 Antibody (9D662) can be used in IHC-P.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Desmocollin 2/DSC2 Antibody (9D662) is a Rabbit antibody targeting Desmocollin 2/DSC2. Anti-Desmocollin 2/DSC2 Antibody (9D662) can be used in IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 9D662 |
| Reactivity | Rat |
| Verified Activity | Immunochemical staining of rat DSC2 in rat heart with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:250-1:1000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Rat DSC2 (rR DSC2; TMPY-03370; Q3T1K6; Met1-Pro694). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rat DSC2 Protein (TMPY-03370) |
| Antigen Species | Rat |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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