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Enflicoxib

Name: Enflicoxib
Brand: TargetMol
SKU: T27233
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27233Cas No. 251442-94-1

Alias E6087, E 6087

Enflicoxib is an efficacious and safe agent for the treatment of pain and inflammation across all stages of canine osteoarthritis. Enflicoxib demonstrates a faster onset of action compared to mavacoxib, offering an improved pharmacological profile for veterinary applications.

Enflicoxib

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Purity: 99.88%

Catalog No. T27233Alias E6087, E 6087Cas No. 251442-94-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Enflicoxib is an efficacious and safe agent for the treatment of pain and inflammation across all stages of canine osteoarthritis. Enflicoxib demonstrates a faster onset of action compared to mavacoxib, offering an improved pharmacological profile for veterinary applications.
In vivo	Pharmacokinetic studies of Enflicoxib were conducted following single oral and intravenous administration in rats and dogs. In both animal species, E-6087 was characterized by a long elimination half-life (20-35 hours), low plasma clearance (0.10-0.22 l h(-1) kg(-1)), and a relatively large volume of distribution (2-6 l kg(-1)). Oral bioavailability was lower in dogs compared to rats, while absorption occurred more rapidly in rats. [2]
Synonyms	E6087, E 6087

Chemical Properties

Molecular Weight	405.34
Formula	C₁₆H₁₂F₅N₃O₂S
Cas No.	251442-94-1
Smiles	O=S(=O)(N)C1=CC=C(C=C1)N2N=C(CC2C3=CC=C(F)C=C3F)C(F)(F)F
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (197.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4671 mL	12.3353 mL	24.6706 mL	123.3532 mL
5 mM	0.4934 mL	2.4671 mL	4.9341 mL	24.6706 mL
10 mM	0.2467 mL	1.2335 mL	2.4671 mL	12.3353 mL
20 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1677 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL	2.4671 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc