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Enflicoxib

Name: Enflicoxib
Brand: TargetMol
SKU: T27233
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27233Cas No. 251442-94-1

Alias E6087, E 6087

Enflicoxib is an efficacious and safe agent for the treatment of pain and inflammation across all stages of canine osteoarthritis. Enflicoxib demonstrates a faster onset of action compared to mavacoxib, offering an improved pharmacological profile for veterinary applications.

Enflicoxib

🥰Excellent

Purity: 99.88%

Catalog No. T27233Alias E6087, E 6087Cas No. 251442-94-1

Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$199	In Stock

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Purity:99.88%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Enflicoxib is an efficacious and safe agent for the treatment of pain and inflammation across all stages of canine osteoarthritis. Enflicoxib demonstrates a faster onset of action compared to mavacoxib, offering an improved pharmacological profile for veterinary applications.
In vivo	Pharmacokinetic studies of Enflicoxib were conducted following single oral and intravenous administration in rats and dogs. In both animal species, E-6087 was characterized by a long elimination half-life (20-35 hours), low plasma clearance (0.10-0.22 l h(-1) kg(-1)), and a relatively large volume of distribution (2-6 l kg(-1)). Oral bioavailability was lower in dogs compared to rats, while absorption occurred more rapidly in rats. [2]
Synonyms	E6087, E 6087

Chemical Properties

Molecular Weight	405.34
Formula	C₁₆H₁₂F₅N₃O₂S
Cas No.	251442-94-1
Smiles	O=S(=O)(N)C1=CC=C(C=C1)N2N=C(CC2C3=CC=C(F)C=C3F)C(F)(F)F
Relative Density.	1.57 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (197.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4671 mL	12.3353 mL	24.6706 mL	123.3532 mL
5 mM	0.4934 mL	2.4671 mL	4.9341 mL	24.6706 mL
10 mM	0.2467 mL	1.2335 mL	2.4671 mL	12.3353 mL
20 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1677 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL	2.4671 mL
100 mM	0.0247 mL	0.1234 mL	0.2467 mL	1.2335 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc