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palovarotene

Catalog No. T4538   CAS 410528-02-8
Synonyms: Ro 3300074, R 667

Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).

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palovarotene Chemical Structure
palovarotene, CAS 410528-02-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 33.00
5 mg In stock $ 68.00
10 mg In stock $ 113.00
25 mg In stock $ 263.00
50 mg In stock $ 419.00
1 mL * 10 mM (in DMSO) In stock $ 109.00
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Purity: 98.05%
Purity: 96.89%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
In vivo Palovarotene inhibits post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation. Palovarotene inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Palovarotene (1 mg/kg/day ) is given orally for 14 days starting on a postoperative day (POD) 1 or POD-5, and HO amount wound dehiscence and related processes are monitored for up to 84 days post-injury. Compared to vehicle-control animals, Palovarotene significantly decreases HO by 50 to 60% regardless of when the treatment started and if the infection is present[1]. Starting from day 1 of injury, half of the Acvr1cR206H/+ mice are treated with Palovarotene by daily gavage for 14 days and the other half received a vehicle as control. Analysis by mCT and 3D image reconstruction at day 14 shows that large HO tissue masses have formed in the targeted leg of Acvr1cR206H/+ mutant mice receiving the vehicle, but HO formation is greatly diminished in Palovarotene-treated companions by more than 80% based on bone volume/total volume quantification[2].
Synonyms Ro 3300074, R 667
Molecular Weight 414.54
Formula C27H30N2O2
CAS No. 410528-02-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.5 mg/mL (13.27 mM)

TargetMolReferences and Literature

1. Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67. 2. Chakkalakal SA, et al. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res. 2016 Sep;31(9):1666-75.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Reprogramming Compound Library Neuronal Differentiation Compound Library Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library Orally Active Compound Library NO PAINS Compound Library

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Keywords

palovarotene 410528-02-8 Autophagy Metabolism Retinoid Receptor RAR/RXR inhibit Retinoid X receptors R667 Ro 3300074 R 667 Ro-3300074 Retinoic acid receptors Inhibitor R-667 Ro3300074 inhibitor

 

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