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Alizapride hydrochloride

Name: Alizapride hydrochloride
Brand: TargetMol
SKU: T2574
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2574Cas No. 59338-87-3

Alias Alizapride HCl

Alizapride hydrochloride (Alizapride HCl) is a dopamine receptor antagonist used for the treatment of nausea and vomiting.

Alizapride hydrochloride

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Purity: 99.48%

Catalog No. T2574Alias Alizapride HClCas No. 59338-87-3

Alizapride hydrochloride (Alizapride HCl) is a dopamine receptor antagonist used for the treatment of nausea and vomiting.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$40	In Stock	In Stock
100 mg	$64	In Stock	In Stock
500 mg	$155	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.48%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Alizapride hydrochloride (Alizapride HCl) is a dopamine receptor antagonist used for the treatment of nausea and vomiting.
In vitro	Intravenous administration of 5 mg/kg Alizapride in rats effectively counteracts the reduction in gastrointestinal motility induced by the given dose of Apomorphine. Alizapride exhibits low toxicity in mice and rats, particularly when administered extragastrically. Following oral or extragastric administration, Alizapride is primarily excreted in its unmodified form; however, approximately 25% of Alizapride undergoes metabolic transformation before excretion.
In vivo	Alizapride contains an N-allyl moiety, which may undergo N-deallylation and/or epoxidation, potentially leading to the formation of chemically reactive metabolites.
Synonyms	Alizapride HCl

Chemical Properties

Molecular Weight	351.83
Formula	C₁₆H₂₁N₅O₂·HCl
Cas No.	59338-87-3
Smiles	Cl.COc1cc2[nH]nnc2cc1C(=O)NCC1CCCN1CC=C
Relative Density.	1.224 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (142.11 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 40 mg/mL (113.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8423 mL	14.2114 mL	28.4228 mL	142.1141 mL
5 mM	0.5685 mL	2.8423 mL	5.6846 mL	28.4228 mL
10 mM	0.2842 mL	1.4211 mL	2.8423 mL	14.2114 mL
20 mM	0.1421 mL	0.7106 mL	1.4211 mL	7.1057 mL
50 mM	0.0568 mL	0.2842 mL	0.5685 mL	2.8423 mL
100 mM	0.0284 mL	0.1421 mL	0.2842 mL	1.4211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc