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Alizapride hydrochloride

Name: Alizapride hydrochloride
Brand: TargetMol
SKU: T2574
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2574Cas No. 59338-87-3

Alias Alizapride HCl

Alizapride hydrochloride (Alizapride HCl) is a dopamine receptor antagonist used for the treatment of nausea and vomiting.

Alizapride hydrochloride

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Purity: 99.48%

Catalog No. T2574Alias Alizapride HClCas No. 59338-87-3

Alizapride hydrochloride (Alizapride HCl) is a dopamine receptor antagonist used for the treatment of nausea and vomiting.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$68	In Stock	In Stock
500 mg	$163	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

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COA

Product Introduction

Bioactivity

Description	Alizapride hydrochloride (Alizapride HCl) is a dopamine receptor antagonist used for the treatment of nausea and vomiting.
In vitro	Intravenous administration of 5 mg/kg Alizapride in rats effectively counteracts the reduction in gastrointestinal motility induced by the given dose of Apomorphine. Alizapride exhibits low toxicity in mice and rats, particularly when administered extragastrically. Following oral or extragastric administration, Alizapride is primarily excreted in its unmodified form; however, approximately 25% of Alizapride undergoes metabolic transformation before excretion.
In vivo	Alizapride contains an N-allyl moiety, which may undergo N-deallylation and/or epoxidation, potentially leading to the formation of chemically reactive metabolites.
Synonyms	Alizapride HCl

Chemical Properties

Molecular Weight	351.83
Formula	C₁₆H₂₁N₅O₂·HCl
Cas No.	59338-87-3
Smiles	Cl.COc1cc2[nH]nnc2cc1C(=O)NCC1CCCN1CC=C
Relative Density.	1.224 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (142.11 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 40 mg/mL (113.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.68 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8423 mL	14.2114 mL	28.4228 mL	142.1141 mL
5 mM	0.5685 mL	2.8423 mL	5.6846 mL	28.4228 mL
10 mM	0.2842 mL	1.4211 mL	2.8423 mL	14.2114 mL
20 mM	0.1421 mL	0.7106 mL	1.4211 mL	7.1057 mL
50 mM	0.0568 mL	0.2842 mL	0.5685 mL	2.8423 mL
100 mM	0.0284 mL	0.1421 mL	0.2842 mL	1.4211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc