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Tizoxanide

Name: Tizoxanide
Brand: TargetMol
SKU: T2279
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2279Cas No. 173903-47-4

Alias TIZ, Desacetyl-nitazoxanide

Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

Tizoxanide

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Purity: 99.28%

Catalog No. T2279Alias TIZ, Desacetyl-nitazoxanideCas No. 173903-47-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$46	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$233	In Stock	In Stock
100 mg	$346	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.28%

Color:White

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Product Introduction

Tizoxanide AI Summary

Tizoxanide exhibits a broad spectrum of bioactivities, including antimicrobial, antiviral, antiprotozoan, and antitumor properties. It inhibits Giardia lamblia recombinant nitroreductase 1 in Escherichia coli with more than 75% inhibition at 5 μM, and shows activity against Clostridium difficile with MIC50 of 0.06 μg/mL and MIC90 of 0.125 μg/mL. Against Mycobacterium tuberculosis H37Rv, it has a Minimum Inhibitory Concentration (MIC) of 16.0 μg/mL in liquid medium after 7 days. It demonstrates antiviral efficacy against HCV genotypes 1a and 1b with EC50 values ranging from 150.0 nM to 2.0 μM and cytotoxicity in human cells with CC50 values of 14,000.0 nM to 92,000.0 nM, along with high selectivity indices. It also exhibits potent antiviral activity against HBV with EC50 values of 150.0 nM and 460.0 nM and low toxicity (CC50 > 100,000.0 nM). For HBV-infected HepG2(2.2.15) cells, it inhibits extracellular and intracellular viral DNA with EC90 values of 0.58 μM and 1.2 μM respectively. Against Trichomonas vaginalis, it has an IC50 of 211.0 nM and displays antiprotozoan activity against various pathogens, including Giardia intestinalis and Leishmania mexicana. The compound shows antimicrobial activity against Mycobacterium tuberculosis in both replicating and non-replicating states with a MIC of 60,380.0 nM, and against Staphylococcus epidermidis with a MIC of 8.0 μg/mL. It has been reported to exert antitumor growth inhibition across multiple human cancer cell lines with GI50 values ranging from 3,000 nM to 40,000 nM. Additionally, Tizoxanide inhibits IL-6 induced STAT3 transcriptional activity in HEK-Blue IL-6 cells, showing 60% inhibition at 10 μM and an IC50 of 8,900.0 nM, while exhibiting 12.7% cytotoxicity in HeLa cells. In animal models, it has a rapid elimination half-life of 0.7 hours in Sprague-Dawley rats when administered via oral gavage. Furthermore, it demonstrates binding affinity with human plasma proteins at 97.5% and a favorable selectivity index, indicating potential therapeutic applications across various medical conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).
Synonyms	TIZ, Desacetyl-nitazoxanide

Chemical Properties

Molecular Weight	265.25
Formula	C₁₀H₇N₃O₄S
Cas No.	173903-47-4
Smiles	Oc1ccccc1C(=O)Nc1ncc(s1)[N+]([O-])=O
Relative Density.	1.644 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (75.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7700 mL	18.8501 mL	37.7003 mL	188.5014 mL
5 mM	0.7540 mL	3.7700 mL	7.5401 mL	37.7003 mL
10 mM	0.3770 mL	1.8850 mL	3.7700 mL	18.8501 mL
20 mM	0.1885 mL	0.9425 mL	1.8850 mL	9.4251 mL
50 mM	0.0754 mL	0.3770 mL	0.7540 mL	3.7700 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc