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Anti-LAMP3/CD208 Antibody (3R433)
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Catalog No. TMAY-00947
Alias lysosomal associated membrane protein 3, LAMP3
Anti-LAMP3/CD208 Antibody (3R433) is a Rabbit antibody targeting LAMP3/CD208. Anti-LAMP3/CD208 Antibody (3R433) can be used in ICC/IF.
Anti-LAMP3/CD208 Antibody (3R433)
Anti-LAMP3/CD208 Antibody (3R433)
😃Good
Catalog No. TMAY-00947Alias lysosomal associated membrane protein 3, LAMP3
Anti-LAMP3/CD208 Antibody (3R433) is a Rabbit antibody targeting LAMP3/CD208. Anti-LAMP3/CD208 Antibody (3R433) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $94 | 7-10 days | |
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ICC/IF Reactivity: Human |
| Alias | lysosomal associated membrane protein 3, LAMP3 |
| Ig Type | Rabbit IgG |
| Clone | 3R433 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Human LAMP3 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human LAMP3 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and countstained with DAPI (blue). Positive staining was localized to cytoplasm. |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD208 / DC-LAMP / LAMP3 (rh CD208 / DC-LAMP / LAMP3; TMPY-01013; NP_055213.2; Lys28-Thr381). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in the activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD208 / DC-LAMP / LAMP3 protein (TMPY-01013) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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