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GSK1733953A

🥰Excellent
Catalog No. T27453Cas No. 930470-97-6
Alias DG70

GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 ± 0.6 μM.GSK1733953A is a selective biphenylbenzamide with an inhibitory effect on the catalytic methylation of the Mycobacterium tuberculosis desmethylnaphthoquinone methyltransferase, and the MIC of GSK1733953A against Mycobacterium tuberculosis H4Rv was 8.37 μg/ml. MIC of 8.37 μg/ml and MIC of 1.2 to 9.6 μg/ml against drug-resistant strains.GSK1733953A is a candidate compound for the treatment of tuberculosis.

GSK1733953A

GSK1733953A

🥰Excellent
Purity: 99.45%
Catalog No. T27453Alias DG70Cas No. 930470-97-6
GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 ± 0.6 μM.GSK1733953A is a selective biphenylbenzamide with an inhibitory effect on the catalytic methylation of the Mycobacterium tuberculosis desmethylnaphthoquinone methyltransferase, and the MIC of GSK1733953A against Mycobacterium tuberculosis H4Rv was 8.37 μg/ml. MIC of 8.37 μg/ml and MIC of 1.2 to 9.6 μg/ml against drug-resistant strains.GSK1733953A is a candidate compound for the treatment of tuberculosis.
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10 mg$30In Stock
50 mgPreferentialIn Stock
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Purity:99.45%
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Product Introduction

Bioactivity
Description
GSK1733953A can be used as a small molecule Mycobacterium tuberculosis respiration inhibitor with an inhibitory effect on MenG activity and an IC50 value of 2.6 ± 0.6 μM.GSK1733953A is a selective biphenylbenzamide with an inhibitory effect on the catalytic methylation of the Mycobacterium tuberculosis desmethylnaphthoquinone methyltransferase, and the MIC of GSK1733953A against Mycobacterium tuberculosis H4Rv was 8.37 μg/ml. MIC of 8.37 μg/ml and MIC of 1.2 to 9.6 μg/ml against drug-resistant strains.GSK1733953A is a candidate compound for the treatment of tuberculosis.
Targets&IC50
MenG:2.6 ± 0.6 μM
SynonymsDG70
Chemical Properties
Molecular Weight385.82
FormulaC21H17ClFNO3
Cas No.930470-97-6
SmilesO(C)C1=C(C=C(NC(=O)C2=C(Cl)C=C(F)C=C2)C=C1)C3=CC=C(OC)C=C3
Relative Density.1.295 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (103.68 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5919 mL12.9594 mL25.9188 mL129.5941 mL
5 mM0.5184 mL2.5919 mL5.1838 mL25.9188 mL
10 mM0.2592 mL1.2959 mL2.5919 mL12.9594 mL
20 mM0.1296 mL0.6480 mL1.2959 mL6.4797 mL
50 mM0.0518 mL0.2592 mL0.5184 mL2.5919 mL
100 mM0.0259 mL0.1296 mL0.2592 mL1.2959 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Mycobacterium tuberculosisGSK1733953ADG-70DG 70Bacterial
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