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Ethylvanillin

Name: Ethylvanillin
Brand: TargetMol
SKU: T0491
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0491Cas No. 121-32-4

Alias Rhodiarome, Ethylprotal, Ethyl vanillin, Bourbonal

Ethylvanillin (Rhodiarome) is a flavorant used in the production of chocolate. It is about three times as potent as vanillin.

Ethylvanillin

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Purity: 99.44%

Catalog No. T0491Alias Rhodiarome, Ethylprotal, Ethyl vanillin, BourbonalCas No. 121-32-4

Ethylvanillin (Rhodiarome) is a flavorant used in the production of chocolate. It is about three times as potent as vanillin.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Ethylvanillin AI Summary

Ethylvanillin demonstrates a range of bioactivities and therapeutic potentials. It exhibits antitubercular activity against Mycobacterium tuberculosis H37Rv, albeit with a relatively low potency, reflected by a Minimum Inhibitory Concentration (MIC) value greater than 400,000 nM. The compound shows varying degrees of potency in several assays: 25,118.9 nM in inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1), 7,943.3 nM in the Cell Viability assay, 7,079.5 nM as a small molecule agonist of retinoid X receptor alpha signaling, and 50,118.7 nM as an antagonist of peroxisome proliferator-activated receptor delta signaling. It also inhibits the growth of various human tumor cell lines with specific GI50 values such as 100,000.0 nM in several cancer cell lines, and lower GI50 values in SR Leukemia (76,032.63 nM) and SNB-75 CNS cell lines (95,060.48 nM). Additionally, it acts as an agonist in the antioxidant response element (ARE) signaling pathway with a potency of 74,978.0 nM. In the context of envenomation, Ethylvanillin provides protection against venom-induced mortality and hemorrhage from Daboia russellii and Naja kaouthia in Swiss albino mice. This efficacy is observed both before and after venom administration, showcasing its potential as an antivenom agent. The compound has a lipophilicity value of 1.81, indicating decent solubility in lipids. For viral infections, Ethylvanillin exhibits modest antiviral activity against SARS-CoV-2. It inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 and Vero-6 cells at a 10 μM concentration, with inhibition rates of -2.44% and -0.06% respectively, after 48-hour exposures. Furthermore, it shows 8.127% inhibition of the SARS-CoV-2 3CL-Pro protease at a 20 μM concentration. Lastly, Ethylvanillin exhibits inhibitory activity in HDAC6 enzymatic assays, with -10.64% inhibition using a commercial peptide substrate and -3.93% inhibition using a custom peptide substrate, hinting at potential roles in modulating epigenetic targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethylvanillin (Rhodiarome) is a flavorant used in the production of chocolate. It is about three times as potent as vanillin.
Synonyms	Rhodiarome, Ethylprotal, Ethyl vanillin, Bourbonal

Chemical Properties

Molecular Weight	166.17
Formula	C₉H₁₀O₃
Cas No.	121-32-4
Smiles	CCOC1=C(O)C=CC(C=O)=C1
Relative Density.	1.307. Temperature:20.6 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (300.9 mM), Sonication is recommended.

H2O: 12 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0179 mL	30.0897 mL	60.1793 mL	300.8967 mL
5 mM	1.2036 mL	6.0179 mL	12.0359 mL	60.1793 mL
10 mM	0.6018 mL	3.0090 mL	6.0179 mL	30.0897 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.3009 mL	1.5045 mL	3.0090 mL	15.0448 mL
50 mM	0.1204 mL	0.6018 mL	1.2036 mL	6.0179 mL
100 mM	0.0602 mL	0.3009 mL	0.6018 mL	3.0090 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc