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CFT7455

Catalog No. T60024 CAS 2504235-67-8

Synonyms: Cemsidomide

CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3).

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CFT7455, CAS 2504235-67-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 132.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 538.00
25 mg	In stock	$ 868.00
50 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 339.00

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Purity: 97.93%

Biological Description

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Storage & Solubility Information

Description	CFT7455 (Cemsidomide) is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3).
In vitro	CFT7455 enables potent cell growth inhibition in both previously untreated NCIH929 multiple myeloma cell lines with an IC50 of 0.071 nM and NCIH929 cells made resistant to both lenalidomide and pomalidomide with an IC50 of 2.3 nM. CFT7455 promotes the degradation of >75% of steady state IKZF1 in multiple myeloma cells within 1.5 hours at 0.3 nM[1].
In vivo	In mouse xenograft tumor models, CFT7455 (3 μg/kg-100 μg/kg) led to durable tumor regression and demonstrates dose-dependent efficacy[1].

Synonyms	Cemsidomide
Molecular Weight	469.53
Formula	C28H27N3O4
CAS No.	2504235-67-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (42.60 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. David Proia, et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1. 2. Fuchs O. Targeting cereblon in hematologic malignancies. Blood Rev. 2023 Jan;57:100994.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Orally Active Compound Library Anti-Cancer Compound Library Clinical Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Homo-PROTAC cereblon degrader 1 dCBP-1 Thalidomide-O-amido-C6-NH2 TFA E3 ligase Ligand 23 (S,R,S)-AHPC-C4-NH2 hydrochloride (S,R,S)-AHPC-PEG2-NH2 dihydrochloride (S,R,S)-AHPC CRBN ligand-9

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Keywords

CFT7455 2504235-67-8 PROTAC Ligand for E3 Ligase cereblon CFT 7455 Ligands for E3 Ligase anti-cancer agent inhibit Inhibitor orally active CFT-7455 E3 ligase-recruiting Moiety IKZF3 degrader IKZF1 Cemsidomide inhibitor

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