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Medronic acid

Name: Medronic acid
Brand: TargetMol
SKU: T19415
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19415Cas No. 1984-15-2

Alias Methylenediphosphonic acid

Medronic acid (Methylenediphosphonic acid), a methylene-substituted bisphosphonate, exhibits affinity for and adherence to hydroxyapatite crystals within the bone matrix. Accumulating at sites of osteoid mineralization, it is utilized, often in conjunction with radioisotopes, for bone imaging.

Medronic acid

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Purity: 99.80%

Catalog No. T19415Alias Methylenediphosphonic acidCas No. 1984-15-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.80%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Medronic acid AI Summary

Medronic acid is a multi-targeting molecule with diverse bioactivities. It demonstrates varying binding affinities against ornithine transcarbamoylase (OTC) from Streptococcus faecalis, with Ki values ranging from 9,000,000 nM to greater than 20,000,000 nM depending on pH and buffer conditions. As an activator of human cytosolic carbonic anhydrase I, it has an activation constant (KA) of 0.2 mM, and binds various carbonic anhydrase enzymes with Ki values between 730,000 nM and 5,340,000 nM. Additionally, Medronic acid is a potent inhibitor of Escherichia coli F plasmid TraI relaxase Y16F mutant (Ki = 3.0 nM), DNA transfer between tetracycline-resistant and streptomycin-resistant E. coli strains (EC50 = 350.0 nM), and demonstrates cytotoxicity against tetracycline-resistant (EC50 = 510.0 nM) and streptomycin-resistant (EC50 = 870,000 nM) E. coli strains. Its selectivity ratios range from 0.68 to 1700.0. The compound also shows inhibitory activity against thyroid hormone receptor interaction with steroid receptor coregulator 2, human Jumonji Domain Containing 2E, fructose-1,6-bisphosphate aldolase from Giardia Lamblia, and the ERK signaling pathway. It has activities against HADH2, T. brucei phosphofructokinase, histone lysine methyltransferase G9a, and BAZ2B. Furthermore, Medronic acid inhibits red kidney beans purple acid phosphatase (Ki = 140,000.0 nM) and exerts inhibitory effects against human recombinant carbonic anhydrase 2 and 9 and human recombinant MMP-2 with IC50 values of 1,250,000 nM, 860,000 nM, and 49,000 nM respectively. It binds to hydroxyapatite with a measured concentration range of 3.2 to 3.7 mM after 1 hour, showing an activity level of 70.0%. Moreover, Medronic acid displays antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (10 μM, -5.54% inhibition) and VERO-6 cells (10 μM, with inhibition ranges from -0.08% to -0.1%). It also inhibits the SARS-CoV-2 3CL-Pro protease with inhibition percentages of 3.11% and 2.39% at a 20 µM concentration. Lastly, it shows partial inhibition of human HDAC6 enzymatic activity (18.33% inhibition with a commercial peptide substrate, -13.18% inhibition with a custom peptide substrate)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Medronic acid (Methylenediphosphonic acid), a methylene-substituted bisphosphonate, exhibits affinity for and adherence to hydroxyapatite crystals within the bone matrix. Accumulating at sites of osteoid mineralization, it is utilized, often in conjunction with radioisotopes, for bone imaging.
Synonyms	Methylenediphosphonic acid

Chemical Properties

Molecular Weight	176
Formula	CH₆O₆P₂
Cas No.	1984-15-2
Smiles	C(P(=O)(O)O)P(=O)(O)O
Relative Density.	2.111 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1420.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (28.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6818 mL	28.4091 mL	56.8182 mL	284.0909 mL
5 mM	1.1364 mL	5.6818 mL	11.3636 mL	56.8182 mL
10 mM	0.5682 mL	2.8409 mL	5.6818 mL	28.4091 mL
20 mM	0.2841 mL	1.4205 mL	2.8409 mL	14.2045 mL
50 mM	0.1136 mL	0.5682 mL	1.1364 mL	5.6818 mL
100 mM	0.0568 mL	0.2841 mL	0.5682 mL	2.8409 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc