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Calenduloside E

Name: Calenduloside E
Brand: TargetMol
SKU: TJS0928
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TJS0928Cas No. 26020-14-4

Alias Silphioside F

Calenduloside E (Silphioside F) is a pentacyclic triterpene saponin extracted from Panax japonicus. It targets heat shock protein 90 (Hsp90) and has anti-apoptotic effect.

Calenduloside E

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Purity: 98.99%

Catalog No. TJS0928Alias Silphioside FCas No. 26020-14-4

Calenduloside E (Silphioside F) is a pentacyclic triterpene saponin extracted from Panax japonicus. It targets heat shock protein 90 (Hsp90) and has anti-apoptotic effect.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$413	In Stock	In Stock
25 mg	$688	In Stock	In Stock
50 mg	$979	In Stock	In Stock
100 mg	$1,320	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.99%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Calenduloside E AI Summary

Calenduloside E has molluscicidal activity against Biomphalaria glabrata, requiring a minimum concentration of 2.0 ppm to cause mortality after 24 hours. In terms of cytotoxicity, it significantly affects various human cancer cell lines. The compound exhibits cytotoxicity against human NCI-H460 cells, with an IC50 value of 6000.0 nM after 72 hours of incubation. It also shows cytotoxic effects on MCF7, SKBR3, HCT116, and MOLT4 cells, with IC50 values ranging from 11330.0 nM to 18000.0 nM. In addition, Calenduloside E induces apoptosis in MCF7 cells and affects various phases of the cell cycle, with notable activities in viable, early apoptotic, late apoptotic, and necrotic cells after 24 and 48 hours at 11.33 µM. This compound also leads to mitochondrial membrane depolarization, cell cycle arrest, and the accumulation of reactive oxygen species (ROS) in MCF7 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Calenduloside E (Silphioside F) is a pentacyclic triterpene saponin extracted from Panax japonicus. It targets heat shock protein 90 (Hsp90) and has anti-apoptotic effect.
Synonyms	Silphioside F

Chemical Properties

Molecular Weight	632.82
Formula	C₃₆H₅₆O₉
Cas No.	26020-14-4
Smiles	[H][C@@]1(O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC=C3[C@]5([H])CC(C)(C)CC[C@@]5(CC[C@@]43C)C(O)=O)C2(C)C)O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (118.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5802 mL	7.9011 mL	15.8023 mL	79.0114 mL
5 mM	0.3160 mL	1.5802 mL	3.1605 mL	15.8023 mL
10 mM	0.1580 mL	0.7901 mL	1.5802 mL	7.9011 mL
20 mM	0.0790 mL	0.3951 mL	0.7901 mL	3.9506 mL
50 mM	0.0316 mL	0.1580 mL	0.3160 mL	1.5802 mL
100 mM	0.0158 mL	0.0790 mL	0.1580 mL	0.7901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc